Apparatus for effecting chemical separation and SERS...

Chemistry: analytical and immunological testing – Optical result – With fluorescence or luminescence

Reexamination Certificate

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C436S164000

Reexamination Certificate

active

07462493

ABSTRACT:
Sol-gel beds and deposits are utilized for SERS analysis of liquid analytes. The use of the same medium to both separate the chemicals and also for SERS greatly reduces the complexity of such apparatus and enhances the efficiency of the method.

REFERENCES:
patent: 5308495 (1994-05-01), Avnir et al.
patent: 5693152 (1997-12-01), Carron
patent: 0133189 (2001-10-01), None
On-Column Surface-Enhanced Ramon Spectroscopy Detection in Capillary Electrophoresis Using Running Buffers Containing Silve Colloidal Sollutions William F. Nirode Gerald L. Devault and Michael J. Sepaniak (Anal. Chem. 2000, 72, 1866-1871); see especially p. 1867 col. 2, line 9 and Figures 3 and 4.
Molecular-Specific Chromatographic Detector Using Modified SERS Substrates, Keith T. Carron and Brian Kennedy (Anal. Chem. 1995, 67, 3353-3356); see especially Figures 1 and 3.
Determination of Purine Bases by Reversed-Phase High-Performance Liquid Chromatography Using Real-Time Surface-Enhanced Raman Spectroscopy, Rongsheng, Fan Ni, and Therese M. Cotton (Anal. Chem. 1991, 63, 437-442); see especially Figures 1 and 6.
Direct Analysis of High-Performance Think Layer—Chromatography Spots of Nucleic Purine Derivatives by Surface-Enhanced Raman Scattering Spectrometry, Shuichi Kawasaki, Totaro Imasuka, and Nobuhiko Ishibashi (Anal. Chem. 1987 59, 525-527).
Fast Spacially Resolved Surface—Enhanced Raman Spectrometry on a Silver Coated Filter Paper Using Change-Coupled device Detection by Cabalin et al., Anal. Chim. Acta, 1995, v. 310, pp. 337-345.
Silver Coated Capillary tube for Surface-Enhanced Raman Scattering, by Li et al., Vibrational Spectr., 1992 v. 3, pp. 115-120.

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