Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2007-09-04
2007-09-04
Kim, Robert (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S285000, C250S428000, C250S435000, C250S438000, C204S451000
Reexamination Certificate
active
10534301
ABSTRACT:
The present invention relates to an apparatus to dispense a sample for subsequent electrospray ionisation (ESI) mass spectrometry (MS) analysis, to a method of fabricating such apparatus and to applications of such apparatus in biological and chemical analysis. The apparatus consists of an electrically non-conductive substrate comprising at least two covered microstructures (generally microchannels) having one extremity formed at the edge of the substrate, one of said microstructures containing the sample to be dispensed into a mass spectrometer by electrospray ionisation and at least a second of said microstructure containing a fluid used as sheath liquid or sheath gas, said at least two microstructures being formed in such a manner that the sample and the sheath liquid/gas come in contact to each other and/or are mixed directly in the Taylor cone of the spray.
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EPODOC, two page English language Abstract for JP 11-002622 A, Jan. 1999.
Reymond Frédéric
Rossier Joël Stéphane
Diagnoswiss S.A.
Howson & Howson LLP
Kim Robert
Souw Bernard
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