Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1990-10-26
1992-06-02
Housel, James C.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 8203, 422 8205, 422 51, 436805, 436806, G01N 2101, G01N 2520, G01N 27416
Patent
active
051184737
ABSTRACT:
An apparatus for correcting an initial measurement of the concentration of a first water soluble species dissolved in a water-based component of a biological fluid that also includes a second water soluble species and a volume occupying component, the initial measurement having been taken using an original sample of the fluid that had been diluted by an amount of additional aqueous solution to form a diluted sample is disclosed; the concentration of the second water soluble species is measured in an undiluted sample of the biological fluid to obtain a direct concentration and is measured using a diluted sample of the fluid to obtain an indirect concentration, and the initial measurement of concentration of the first species is adjusted based on a combination of the direct and indirect concentration determination of the second species. The apparatus includes a first measurement device, which may be a colorimeter or amperometer, for measuring the diluted first species concentration; a second measurement device, which may be an indirect potentiometer, for measuring the diluted second species concentration; a third measurement device, which may be an ion selective electrode, for measuring the undiluted second species concentration; in particular embodiments, additional measurement devices, which may be a gas sensor and a spectrophotometer, for measuring the concentration of species which may complex with second species, and a computer connected to the various measurement devices.
REFERENCES:
patent: 4965049 (1990-10-01), Lillig et al.
Coleman et al., "Evidence for Formation of Bicarbonate Complexes with N.sup.a and K.sup.+ under Physiological Conditions," Clin. Chem. 27: 1938-1939, (1981).
Shyr et al., "Effect of Sample Protein Concentration on Results of Analysis for Sodium and Potassium in Serum," Clin. Chem. 26: 1517 (198).
Coleman Robert L.
Young Chung C.
Housel James C.
Nova Biomedical Corporation
Redding David
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