Surgery – Truss – Pad
Patent
1992-11-23
1994-09-13
Cohen, Lee S.
Surgery
Truss
Pad
128743, A61B 500
Patent
active
053459431
ABSTRACT:
An apparatus for determining in vivo hyperalgesia to thermal stimulation in an unrestrained subject within a predetermined space permitting the selective application of radiant heat to a site of the subject comprises a timer, a movable light source, a light detector and a stopper for the timer, the light source and the detector, the stopper being electrically connected thereto and automatically activated by the light detector upon site withdrawal, and a starter for the timer and the light source and for activating the light detector that is electrically connected thereto. When the light source is aimed at the site and positioned at a distance effective to locally provide radiant heat thereto and the starter is activated, after a latency time period the light beam elicits a spontaneous withdrawal response from the subject that is detected by the detector. The timer, the light source and detector, the stopper and the starter are part of an electrical circuit which is to be connected to a power source prior to use.
REFERENCES:
patent: 3304911 (1967-02-01), Hakata et al.
patent: 3439358 (1969-04-01), Salmons
patent: 3540413 (1970-11-01), Castaigne et al.
patent: 3826229 (1974-07-01), Class et al.
patent: 3935485 (1976-01-01), Yoshida et al.
patent: 3970862 (1976-07-01), Edelman et al.
patent: 4090212 (1978-05-01), Byatt et al.
patent: 4115692 (1978-09-01), Balcerak et al.
patent: 4337726 (1982-07-01), Czekajewski et al.
patent: 4574734 (1986-03-01), Mandalaywala et al.
Siegmund et al., "A Method for Evaluating both Non-Narcotic and Narcotic Analgesics", PSEMB v. 95 (1957).
Eddy et al., "Synthetic Analgesics II. Dithienylbutenyl- and Dithienylbutylamines", National Institute of Arthritis and Metabolic Diseases, pp. 385-393 (1952).
D'Amour et al., "A Method for Determining Loss of Pain Sensation", The Biologic Research Laboratory, pp. 74-79, (1941).
Ercoli et al., Studies on Analgesics, The Research Laboratories, Hoffman La-Roche, pp. 301-317.
Joris, J., Dubner, R., Brown, F., Flores, C., and Hargreaves, K.: "Behavorial and Endocrine Correlates of Thermal Nociception in Carrageenin-Induced Cutaneous Hyperalgesia", Abs. Soc. Neurosci. 1986.
Joris, J., Dubner, R., and Hargreaves, K.: "Involvement of the Peripheral Nervous System in Carrageenan-Induced Inflammation", Abs. Soc. Neurosci. 1987.
Hargreaves, K. and Joris, J.: "Opiates Suppress Carrageenan-Induced Inflammation", Abs. Soc. Neurosci. 13: 1017, 1987.
Costello, A. H., and Hargreaves, K. M.: "Peptide Analogs of Bradykinin (BK) Inhibit Carrageenan-Induced Inflammation", America Pain Society Abstract #SS 2d, 1988. Toronto, Canada.
Hargreaves, K. M., Joris, J. and Dubner, R.: "Peripheral Actions of Opiates in the Blockade of Carrageenan-Induced Cutaneous Hyperalgesia", Pain (Suppl. 4): S17, 1987 Hamburg, Fed. Rep. of Germany.
Hargreaves, K. M., Carson, D. and Costello, A.: "Corticotropin Releasing Factor (CRF) Analgesia: Evaluation of Pituitary and Adrenal Gland Mediation", Abst. Submitted for the 1989 meeting of the American Association for Dental Research 1989.
J. L. Joris, MD, R. Dubner, DDS, PhD, and K. M. Hargreaves, DDS, PhD "Opioid Analgesia at Peripheral Sites: A Target for Opioids Release during Stress and Inflammation?" ANESTH ANALG 1987; 66:1277-81.
Kenneth M. Hargreaves, Ronald Dubner and Jean Joris, "Peripheral actions of opiates in the blockade of carrageenan-induced inflammation" 1988.
Robert I. Taber, "Predictive Value of Analgesic Assays in Mice and Rats" pp. 191-211.
Kenneth M. Hargreaves, Ann H. Costello and Jean L. Joris, "Release From Inflames Tissue of a Substance with Properties Similar to Corticotropin Releasing Factor" Manuscript 88-118 revised.
K. Hargreaves, R. Dubner, F. Brown, C. Flores and J. Joris, "A new and Sensitive method for measuring thermal nociception in cutaneous hyperalgesia" Pain, 32 (1988) 77-88 (Basic Section).
K. Hargreaves, Emanuel S. Troullos, Raymond A. Dionne, Elizabeth A. Schmidt, Susan C. Schafer and Jean Joris, "Bradykinin is increased during acute and chronic inflammation: Therapeutic implications" Dec. 88 Issue of Clin, Pharm. Ther.
Eaden F. Keith, "Evaluation of Analgesic Substances" American J. Pharm. 132: 202-230 (1960).
G. Woolfe and A. D. MacDonald, "The Evaluation of the Analgesic Action of Pethidine Hydrochloride (Dermerol)", J. Pharmacology and Experimental Theropeutics 80, 300-307 (1944).
Lowell O. Randall and Joseph J. Selitto, "A Method for Measurement of Analgesic Activity on Inflamed Tissue" Arch. int. pharmacodyn., 1957, CXI, No. 4.
S. H. Ferreira, "Prostaglandins, Aspirin-like Drugs and Analgesia", Nature New Biology 240:200-203 (1972).
Weiner et al, "Neurohumoral Transmission: The Autonomic and Somatic Motor Nervous System", in The Pharmacological Basis of Therapeutics, Gilman & Goodman, N.Y., McMillan Publishers, 7ED p. 505 (1985).
Levine et al, "Noradrenaline Hyperalgesis is Mediated Through Interaction with Sympathetic Post-ganglionic Neurone Terminals Rather than Activation of Primary Afferent Nociceptors", Nature 323:158-169, (1986).
Hermens, et al, "Comparison of Histamine Release in Human Skin Mast Cells Induced by Morphine, Fentanyl & Oxymorphone", Anesthesiology 62:124-129 ('85).
Brown Fred
Dubner Ronald
Hargreaves Kenneth M.
Cohen Lee S.
Lacyk John P.
The United States of America as represented by the Secretary of
LandOfFree
Apparatus for determining in vivo response to thermal stimulatio does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus for determining in vivo response to thermal stimulatio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for determining in vivo response to thermal stimulatio will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1113650