Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone
Patent
1992-07-07
1994-11-22
Green, Randall L.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
Bone
623 11, 623 66, 424422, 424423, A61F 228, A61F 202, A61F 1300, A61F 200
Patent
active
053665082
ABSTRACT:
Device and method for treating mammalian bone deficiencies, defects, voids and conformational discontinuities produced by congenital deformities, osseous and/or soft tissue pathology, traumatic injuries and functional atrophy is described. The device is a one piece molded body member composed of four substances, each of which contributes to the device, a specific requirement (or requirements) for osteogenesis and/or osteoneogenesis. Taken as a whole, the functions of these device constituents are integrated into a single body member which, when implanted into a bone defect, has the capacity to restore functional architecture and mechanical integrity, initiate osteoinduction and osteogenesis, and maintain the biological process of bone formation and remodeling while the host organism is simultaneously biodegrading the body member. The ultimate result of the functioning is formation of healthy, viable bone tissue where there was not bone before, while, simultaneously, the entire device is hydrolyzed and completely metabolized by the host organism. The device comprises four disparate elements: POLYLACTIC ACID, HYALURONIC ACID BONE MORPHOGENETIC PROTEIN and BONE DERIVED GROWTH FACTOR. Working together, these elements provide the following five biological functions prerequisite to the processes of osteoneogenesis: structural competence (polylactic acid), chemotaxis (hyaluronic acid), electronegative field (hyaluronic acid and physical-chemical electrokinetic events), osteoinduction (bone morphogenetic protein), and osteogenesis (bone derived growth factor).
REFERENCES:
patent: 3739773 (1973-06-01), Schmitt et al.
patent: 4186448 (1980-02-01), Brekke
patent: 4279249 (1981-07-01), Vert et al.
patent: 4419340 (1983-12-01), Yolles
patent: 4442655 (1984-04-01), Stroetmann
patent: 4563489 (1986-01-01), Urist
patent: 4596574 (1986-06-01), Urist
patent: 4609551 (1986-09-01), Caplan et al.
patent: 4636526 (1987-01-01), Dorman
patent: 4713076 (1987-10-01), Draenert
Noonan "Effect of fibronectin on the adhesion of an established cell line to a surface reactive biomaterial," Journal of Biomed Mat Res, vol. 16, p. 195-207 (1982).
"Calcium Phosphate Ceramics as Hard Tissue Prosthetics," by Michael Jarcho, PhD., Clinical Orthopedica and Related Research No. 157, Jun., 1981, pp. 259-278.
Biomedical Materials Symposium No. 2, "Bioceramics-Engineering in Medicine (Part I)," 1972, pp. 91-115; 161-229; and 269-279.
Biomedical Materials Symposium No. 2, "Bioceramics-Engineering in Medicine (PART 2)," 1972, pp. 311-332 and 345-361.
"Developmental Role of Hyaluornate," by Bryan Toole, Connective Tissue Research, 1982, vol. 10, pp. 93-100.
"Healing of Hyaluronic Acid-Enriched Wounds: Histological Observations," by Abatangelo et al., Journal of Surgical Research 35, pp. 410-416 (1983).
"B-tricalcium Phosphate Delivery System for Bone Morphogenetic Protein," by Urist et al., Clinical Orthopaedics and Related Research, No. 1987, Jul./Aug. 1984, pp. 277-278.
"Effect of the Structure of Poly(Glycol Monomethacrylate) Gel on the Calcification of Implants," by Sprincl, Kopecek and Lim, Calc. Tiss. Res. 13, 63-72 (1973), pp. 63-72.
"Influence of polylactic acid mesh on the incidence of localized osteitis," by Brekke, Olson, Scully, and Osbon, Oral Surgery, vol. 56, Sep., 1983, pp. 240-245.
"Effect of Surgical Trauma and Polylacttate Cubes and Granules on the Incidence of Alveolar Osteitis in Mandibular Third Molar Extraction Wounds," by Brekke, et al., J Canad Dent. Assn., No. 4, 1986, pp. 315-319.
"Human Bone Morphogenetic Protein (hBMP) (41630)," by Urist et al., Proceedings of the Society for Experimental Biology and Medicine 173, 194-99 (1983).
Green Randall L.
Nguyen Dinh X.
THM Biomedical, Inc
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