Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1990-02-23
1991-09-17
Pellegrino, Stephen C.
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604905, A61M 532
Patent
active
050491393
DESCRIPTION:
BRIEF SUMMARY
This invention relates to an antimicrobial composition for use in medicine. The invention also relates to a device for use in medicine, which embodies the said composition and to a method of inhibiting or combating infection.
The antimicrobial action of silver ions is well known as are pharmaceutical formulations containing silver salts as active principle. Perhaps the best known example of such materials is silver sulphadiazine. However, silver nitrate and silver allantoinate are also used as antimicrobials.
For protracted protection against infection it is desirable that the release of the silver ion be sustained over an extended period of time.
It is known that certain glasses, in which the usual glass former, silicon dioxide, of traditional glasses is replaced with phosphorus pentoxide as the glass former, are soluble in water and body fluids. The rate of dissolution is controlled largely by the addition of glass modifiers such as calcium and magnesium oxide. In simple terms, the greater the concentration of the modifier the slower is the rate of dissolution. The rates of dissolution which can be imparted to the lasses may range from minutes to months or even to several years. It is known to include in such compositions quantities of trace elements such as copper, cobalt and selenium which will be released from the glass as it slowly dissolves over the selected period of time.
The use of water-soluble glasses has been described for a variety of purposes in the literature. For example, UK Patent Specifications numbers 1,565,906, 2,079,152, 2,077,585 and 2,146,531 describe the gradual dissolution of the glasses as providing a means of controlled release of drugs, hormones, fungicides, insecticides, spermicides and other agents with which the glasses have been impregnated. The glasses are used for example in the form of an implant or bolus.
UK Patent Specification number 2,030,559 describes the use of selenium-impregnated water-soluble glass for providing controlled release of the selenium as a trace element into cattle and sheep, the glass being applied as a subcutaneous insert. UK Patent Specification number 2,037,735 also describes a subcutaneous implant of water-soluble glass, and in this case the glass is impregnated with copper; minor quantities of trace elements such as boron, arsenic, iodine, manganese, chromium, silver, gold and allium may also be included.
Water-soluble glass has also been proposed for use in prosthetics, for example in UK Patent Specification number 2,099,702, and for use in anticorrosive paints, as described in UK Patent Specification number 2,062,612. Further the literature provides for the use of such glasses in the controlled release of ferrous and ferric ions into the human or animal body by ingestion or implantation of the glass (UK Patent Specification number 2,081,703), and for the use of glasses in the controlled release of ions such as lithium, sodium, potassium, caesium, rubidium, polyphosphate, calcium and aluminium to patients by inclusion of the glass in a drip feed line (UK Patent Specification number 2,057,420).
According to the present invention there is provided apparatus for antimicrobial use in passage of fluid to or from a living body, the apparatus comprising a conduit for insertion into the body, a reservoir for fluid and a connector member for connecting said conduit to said reservoir external of the body, wherein said connector member includes a water-soluble glass impregnated with elemental silver or a compound of silver, said water-soluble glass defining at least a part of a passageway for fluid to flow between the reservoir and the conduit.
The apparatus of the present invention preferably contains the impregnated water-soluble glass at a site at which bacteria can be introduced or increased in number, and the bacteriostatic or bactericidal properties of the silver has the effect of containing or reducing the risk of infection in the body. The connector member may comprise a first portion having an end adapted for connection with said conduit and a s
REFERENCES:
patent: 4354490 (1982-10-01), Rogers
patent: 4559033 (1985-12-01), Stephen et al.
patent: 4564361 (1986-01-01), Akiyama
patent: 4919658 (1990-04-01), Badia
patent: 4933178 (1990-06-01), Capelli
Giltech Limited
Pellegrino Stephen C.
Rafa Michael
LandOfFree
Apparatus for antimicrobial use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus for antimicrobial use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for antimicrobial use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1914255