Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1983-06-13
1985-08-06
Niebling, John F.
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204186, 204301, 204302, 204299R, 210905, B01D 1706, G01N 2726, G01N 2728
Patent
active
045334471
ABSTRACT:
An apparatus for and a method for separating a mixture of proteins containing proteins of different isoelectric points, which method comprises flowing an aqueous feed stream containing the mixture of proteins along a thin-channel flow path established between first and second gas-permeable membranes, diffusing a gas through the first and second membranes and generally transversely across the flow path of the feed stream, the gas selected to establish a gradient in the concentration of the gas and to provide a gradient in pH across the flow path of the feed stream, and, after a defined time period, separating the feed stream into streams containing concentrated fractions of proteins having defined isoelectric points, by virtue of the difference in the direction of diffusion occurring of the proteins in the flow path.
REFERENCES:
patent: 3915839 (1975-10-01), Rilbe et al.
patent: 4204929 (1980-05-01), Bier
patent: 4362612 (1982-12-01), Bier
patent: 4401538 (1983-08-01), Hausfeld
Meldon, J. H., et al, "The Mechanism of Carbon Dioxide Transport in Protein Solutions", Paper Presented at the Annual Convention of the American Institute of Chemical Engineers, Nov. 1982.
Meldon, J. H., et al, "Electrical Potentials Induced by CO.sub.2 Gradients in Protein Solutions and Their Role in CO.sub.2 Transport", Bioelectrochemistry and Bioenergetics, vol. 5, No. 1, 1978, p. 77-87.
Boggs Jr. B. J.
Niebling John F.
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