Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-09-13
2005-09-13
Sisson, Bradley L. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S187000, C702S019000
Reexamination Certificate
active
06942971
ABSTRACT:
An apparatus for determining a threshold value (e.g., a threshold cycle number or a time value) in a nucleic acid amplification reaction comprises a detection mechanism for measuring, at a plurality of different times during the amplification reaction, at least one signal whose intensity is related to the quantity of a nucleic acid sequence being amplified in the reaction. A controller in communication with the detection mechanism is programmed to store signal values defining a growth curve for the nucleic acid sequence, determine a derivative of the growth curve, and calculate a cycle number or time value associated with a characteristic of the derivative.
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LightCycler Operator's Manual Version 3.0, May 1999, Roche Pharmaceuticals.
Borkholder David A.
Christel Lee A.
McMillan William A.
Young Steven J.
Cepheid
Sisson Bradley L.
Townsend and Townsend / and Crew LLP
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