Apparatus and process for multi stage solid phase synthesis of l

Details Apparatus and process for multi stage solid phase synthesis of l Apparatus and process for multi stage solid phase synthesis of l

1996-02-29

1998-09-15

McMahon, Timothy

Chemical apparatus and process disinfecting, deodorizing, preser

Chemical reactor

Organic polymerization

422134, 422 62, 422 8205, 422110, 935 88, 73 2504, 73 2901, 7333501, B23B 2700

Patent

active

058075259

ABSTRACT:
An apparatus and process are disclosed for optimizing the repetitive steps in a solid-phase oligonucleotide synthesis by continuous optical scanning of the effluent stream from the reaction module and by computerized processing and implementation of the scanning data.

REFERENCES:
patent: 5126273 (1992-06-01), Sheppard et al.
patent: 5233044 (1993-08-01), Derek Hudson
patent: 5466608 (1995-11-01), Lapluye et al.
Stewart, John M. et al., (1984), "Solid Phase Peptide Synthesis", Pierce Chemical Company (2nd ed.).
Letsinger, R.L., et al. (1965), "Oligonucleotide Synthesis on a Polymer Support", Journal American Chemical Society, 87, 3526-3527.
Agrawal, Sudhir (ed.) (1993), "Protocols for Oligonucleotide and Analogs: Synthesis and Properties", Humana Press, vol. 20 of Methods in Molecular Biology series.

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