Optics: measuring and testing – For optical fiber or waveguide inspection
Patent
1998-04-14
2000-05-30
Kim, Robert H.
Optics: measuring and testing
For optical fiber or waveguide inspection
356318, 356326, 356445, G01B 902, G01N 1100
Patent
active
060696893
ABSTRACT:
Apparatus for diagnosis of a skin disease site using spectral analysis includes a light source for generating light to illuminate the disease site and a probe unit optically connected to the light source for exposing the disease site to light to generate fluorescence and reflectance light. The probe unit also collects the generated fluorescence and reflectance light and transmits this light to a spectrometer to be analyzed. The spectrometer generates and displays spectral measurements of the fluorescence light and the reflectance light which in together assist the user in diagnosing the disease site. The apparatus makes use of a conventional personal computer using a plug-in spectrometer card to provide a compact and low costs system. The system performs combined fluorescence and reflectance spectral analysis in a quick and efficient manner to provide a powerful tool for dermatologic diagnosis.
REFERENCES:
patent: 4718417 (1988-01-01), Kittrell et al.
patent: 4768513 (1988-09-01), Suzuki
patent: 4847198 (1989-07-01), Nelson et al.
patent: 4927222 (1990-05-01), Kamiya et al.
patent: 4930516 (1990-06-01), Alfano et al.
patent: 4957114 (1990-09-01), Zeng et al.
patent: 5042494 (1991-08-01), Alfano
patent: 5131398 (1992-07-01), Alfano et al.
patent: 5261410 (1993-11-01), Alfano
patent: 5280788 (1994-01-01), Janes et al.
patent: 5348018 (1994-09-01), Alfano et al.
patent: 5413108 (1995-05-01), Alfano
patent: 5439000 (1995-08-01), Gunderson et al.
patent: 5452723 (1995-09-01), Wu et al.
patent: 5456260 (1995-10-01), Kollias et al.
patent: 5467767 (1995-11-01), Alfano et al.
patent: 5507287 (1996-04-01), Palcic et al.
patent: 5522868 (1996-06-01), Buckley et al.
patent: 5556612 (1996-09-01), Anderson et al.
patent: 5590660 (1997-01-01), MacAulay et al.
patent: 5601087 (1997-02-01), Gunderson et al.
patent: 5615673 (1997-04-01), Berger et al.
patent: 5647368 (1997-07-01), Zeng et al.
patent: 5687730 (1997-11-01), Doiron et al.
patent: 5693043 (1997-12-01), Kittrell et al.
patent: 5697373 (1997-12-01), Richards-Kortum et al.
patent: 5699795 (1997-12-01), Richards-Kortum et al.
patent: 5701902 (1997-12-01), Vari et al.
patent: 5705518 (1998-01-01), Richter et al.
patent: 5738101 (1998-04-01), Sappey
patent: 5751415 (1998-05-01), Smith et al.
patent: 5753511 (1998-05-01), Selinfreund
patent: 5769081 (1998-06-01), Alfano et al.
patent: 5778016 (1998-07-01), Sucha et al.
patent: 5784162 (1998-07-01), Cabib et al.
patent: 5786893 (1998-07-01), Fink et al.
Andrew J. Berger, et al., Rapid, noninvasive concentration measurements of aqueous biological analytes by near-infrared Raman spectroscopy, Applied Optics, Jan. 1, 1996, vol. 35, No. 1, pp. 209-212.
Zeng, et al., "Optical spectroscopy studies of diseased skin," European BioMedical Optics-BiOS Europe '95, Barcelona, Spain, Sep. 12-16, 1995 (p. 145).
Zeng, et al., "Non-invasive, Bedside Autofluorescence Spectroscopy of Benign and Malignant Skin Lesions," Fourth Meeting of the Western Canadian Society for Clinical and Investigative Dermatology, Jasper, AB, Mar. 24-26, 1995.
Zeng, et al., "Quantative Analysis of Laser Induced Autofluorescence Spectra of Diseased Skin," Photonics China '96, Lasers in Medicine and Dentistry: Dignostics and Treatment, Bejing, China, Nov. 4-7, 1996.
Zeng, et al., "Update on Fluorescence Spectroscopy Studies of Diseased Skin," SPIE BiOS '96, San Jose, CA, Jan. 27-Feb. 2, 1996, Paper 2671E-42, Session 8, p. 12.
Lui, et al., "Ratio Analysis of Reflectance and Fluorescence Spectra of Diseased Skin," 24.sup.th Annual Meeting of the American Society for Photobiology, Atlanta, Georgia, Jun. 15-20, 1996.
Lui, et al., "Optical Spectroscopy as a Potential Diagnostic Aid for Dermatology," Clinical Dermatology 2000--International Congress, Vancouver, BC, May 28-31, 1996, Programme and Abstracts, Abstract 584, p. 176.
Richter, et al., "Photosensitising potency of structural analogues of benzoporphyrin derivative (BPD) in a mouse tumour model," Cancer (1991) 63, 87-93.
Zeng, et al., "Miniature Spectrometer and Multi-Spectral Imager for Skin Diagnoses," Laser in Dermatology, Plastic Surgery and Burn Treatment at Biomedical Optics '95, San Jose, CA, Feb. 4-10, 1995, In: SPiE 238709:17, 1995.
Zeng et al., "Update on fluorescence spectroscopy studies of diseased skin," Conference: Lasers in Dermatology and Plastic Surgery, BiOS '96, Jan. 27-Feb. 2, 1996, San Jose, CA.
Zeng et al., "Optical spectroscopy studies of diseased skin--preliminary results," SPIE vol. 2628 / 281-285 (1995).
Zeng et al., "Miniature spectrometer and multi-spectral imager as a potential diagnostic aid in dermatology," SPIE vol. 2387 / 57-61 (1995).
Richter et al., "Preliminary Studies on a More Effective Phototoxic Agent Than Hematophorphyrin," JNCI. vol. 79. No. 6, Dec., 1987, pp. 1327-1332.
Zeng, et al., "Novel Microspectrophotometer and its Biomedical Applications", Optical Engineering, SPIE vol. 32: No. 8, 1809-1814 (1993).
Zeng, et al., "Laser-induced changes in autofluorescence of in vivo skin", Laser-Tissue Interaction IV, SPIE vol. 1882:278-290 (1993).
Bissonnette R.et al., "Detection of Autofluorescence Due to Protoporphyrin IX in the Stratum Corneum of Ps oriasis Plaques," 25.sup.th Annual Meeting of the American Society for Photobiology, St. Louis, Missouri, Jul. 5-10, 1997.
Zeng, et al., "Reconstruction of in vivo skin autofluorescence spectrum from microscopic properties by Monte Carlo simulation", Journal of Photochemistry and Photobiology B: Biology, 234-240 (1996).
Zeng, et al., "Spectroscopic and Microscopic Characteristics of Human Skin Autofluorescence Emission", Photochemistry and Photobiology, 61:639-645, 1995.
Tanaka K. et al., "Compound parabolic concentrator probe for efficient light collection in spectroscopy of biological tissue", Applied Optics, 35(4):758-763 (1996).
Williams AC et al., "A Critical Comparison of Some Raman Spectroscopic Techniques for Studies of Human Stratum Corneum", Pharmaceutical Research, 10 (11): 1642-1647 (1993).
Williams AC et al., "Comparison of Fourier Transform Raman Spectra of Mammalian and Reptilian Skin", Analyst, vol. 119:563-566 (1994).
Zeng H et al., "A computerized autofluorescence and diffuse reflectance spectroanalyser system for in vivo skin studies", Phys. Med. Biol. vol. 38:231-240 (1993).
Zeng H et al., "Monte Carlo modeling of tissue autofluorescence measurement and imaging", from Proceedings of Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases; SPIE vol. 2135:94-104 (1994).
Barry BW, et al., "Fourier Transform Raman and Infrared Vibrational Study of Human Skin: Assignment of Spectral Bands", Journal of Raman Spectroscopy, 23:641-645 (1992).
Mahadevan-Jansen A. et al., "Raman Spectroscopy for the Detection of Cancers and Precancers," Journal of Biomedical Optics 1(1), 31-70 (Jan. 1996).
Manoharan R.et al., Histochemical analysis of biological tissues using Raman spectroscopy, Spectrochimica Acta Part A 52:215-249 (1996).
Mizuno A.et al., "Near-Infrared Fourier Transform Raman Spectroscopic Study of Human Brain Tissues and Tumours", Journal of Raman Spectroscopy, 25:25-29 (1994).
Ono I. et al., "Magnetic Resonance Imaging for Diagnosing Skin Tumors", Clinics in Dermatology, 13:393-399 (1995).
Redd D. CB et al., Raman Spectroscopic Charaterization of Human Breast Tissues: Implications for Breast Cancer Diagnosis, Applied Spectroscopy, 47:6: 787-791 (1993).
Lui Harvey
MacAulay Calum
McLean David I.
Palcic Branko
Zeng Haishan
Derma Technologies, Inc.
Kim Robert H.
Stafira Michael P.
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