Apparatus and methods for preparing an implantable graft

Details Apparatus and methods for preparing an implantable graft Apparatus and methods for preparing an implantable graft

1998-05-21

2000-04-11

Milano, Michael J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Bone

4241641, 210659, A61F 228, A61K 3940, B01D 1508

Patent

active

060490268

ABSTRACT:
A kit for preparing an implantable graft, particularly an implantable, composite bone graft is provided. The kit includes a porous, biocompatible, sterile substrate and a container configured to retain the substrate and to permit flow of a cell suspension, particularly a bone marrow aspirate suspension therethrough. A method which employs such kit for preparing a composite implantable bone graft is also provided. The method includes the steps of providing a bone marrow aspirate suspension and passing the bone marrow aspirate suspension through a porous, biocompatible, implantable substrate to provide a composite bone graft having an enriched population of connective tissue progenitor cells. The composite bone graft prepared by the present method contains an enriched population of connective tissue progenitor cells and a greater number of connective tissue progenitor cells per unit volume than that found in the original bone marrow aspirate. The present invention also relates to a composite bone marrow graft prepared according to the present method.

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