Chemistry: analytical and immunological testing – Measurement of electrical or magnetic property or thermal...
Reexamination Certificate
2001-02-05
2004-12-28
Snay, Jeffrey R. (Department: 1743)
Chemistry: analytical and immunological testing
Measurement of electrical or magnetic property or thermal...
C436S150000, C436S164000
Reexamination Certificate
active
06835574
ABSTRACT:
FIELD OF THE INVENTION
The invention relates to calorimetry. More particularly, the invention relates to apparatus and methods for performing calorimetry that use optical devices to detect thermal processes and/or multiwell sample plates to support samples for use with such optical devices.
BACKGROUND OF THE INVENTION
Thermodynamics has established the interrelationship between various forms of energy, including heat and work. Moreover, thermodynamics has quantified this interrelationship, showing, for example, that in chemical and physiological processes the difference between the energy of the products and the energy of the reactants is equal to the heat gained or lost by the system. In an “exothermic” process, this difference is negative, so that the process releases heat to the environment. Conversely, in an “endothermic” process, this difference is positive, so that the process absorbs heat from the environment. Thus, “calorimetry,” or the measurement of heat production and/or heat transfer, can be used to determine if a chemical or physiological process is exothermic or endothermic and to estimate the energy produced or consumed.
The measurement of heat production and/or heat transfer in chemical and physiological processes can be quite complicated. Standardly, such measurements are made using a device known as a “bomb calorimeter.” This device typically includes a sturdy steel container with a tight lid, immersed in a water bath and provided with electrical leads to detonate a reaction of interest inside the calorimeter. The heat evolved in the reaction is determined by measuring the increase in temperature of the water bath.
Unfortunately, bomb calorimeters are inadequate for the measurement of heat production and/or heat transfer in many areas of chemistry and physiology. For example, the study of processes involving uncommon and/or expensive components may require analysis of samples too small for bomb calorimetry. Similarly, the high-throughput screening of pharmaceutical drug candidate libraries for drug activity may require analysis of too many samples for bomb calorimetry.
The analysis of small samples is especially problematic due to their small heat capacities and large surface-to-volume ratios. Many chemical and physiological processes lead to very small changes in temperature (<0.05° C.), making their analysis susceptible to environmental contamination. In particular, whenever there is a temperature difference between a sample and the environment, heat can be exchanged between the sample and the environment, for example, by conduction, convection, and/or radiation, among others. Such heat exchange may quickly alter the temperature of a small sample and thereby obscure any temperature change associated with a reaction. Moreover, fluid samples such as those typically used in studies of chemical and physiological processes may initiate secondary reactions with the environment, such as evaporation. Evaporation, by definition, is an exchange of energy (moisture is added to the air, while chemical volume is reduced). This process takes place on the surface of the sample, where the sample is exposed to the environment, and so may be especially problematic for small samples due to their relatively large surface-to-volume ratios. Evaporation not only removes energy from the sample, contaminating the measurement, but also may increase measurement noise due to surface instability as the fluid phase changes to a gas phase.
SUMMARY OF THE INVENTION
The invention provides apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.
REFERENCES:
patent: 2056791 (1936-10-01), Logan
patent: 3013467 (1961-12-01), Minsky
patent: 3540858 (1970-11-01), Rochte et al.
patent: 3849654 (1974-11-01), Malvin
patent: 4011451 (1977-03-01), Nelson
patent: 4024560 (1977-05-01), Miller et al.
patent: 4053381 (1977-10-01), Hamblen et al.
patent: 4067653 (1978-01-01), Fletcher et al.
patent: 4162896 (1979-07-01), Hosli
patent: 4221966 (1980-09-01), Kerr et al.
patent: 4231989 (1980-11-01), Thoma
patent: 4240751 (1980-12-01), Linnecke et al.
patent: 4245052 (1981-01-01), Lund
patent: 4292273 (1981-09-01), Butz et al.
patent: 4332768 (1982-06-01), Berglund
patent: 4397560 (1983-08-01), Andresen
patent: 4461328 (1984-07-01), Kenney
patent: 4498510 (1985-02-01), Minshew, Jr. et al.
patent: 4501970 (1985-02-01), Nelson
patent: 4545958 (1985-10-01), Dopatka
patent: 4591550 (1986-05-01), Hafeman et al.
patent: 4599315 (1986-07-01), Terasaki et al.
patent: 4622208 (1986-11-01), Namba et al.
patent: 4626684 (1986-12-01), Landa
patent: 4669978 (1987-06-01), Klefisch
patent: 4670219 (1987-06-01), Nelson et al.
patent: 4704255 (1987-11-01), Jolley
patent: 4704353 (1987-11-01), Humphries et al.
patent: 4707067 (1987-11-01), Haberland et al.
patent: 4730921 (1988-03-01), Klein et al.
patent: 4735778 (1988-04-01), Maruyama et al.
patent: 4738825 (1988-04-01), Kelln et al.
patent: 4741619 (1988-05-01), Humphries et al.
patent: 4762420 (1988-08-01), Bowley
patent: 4772453 (1988-09-01), Lisenbee
patent: 4788150 (1988-11-01), Nelson et al.
patent: 4801804 (1989-01-01), Rosenthal
patent: 4810096 (1989-03-01), Russell et al.
patent: D303149 (1989-08-01), Andersen
patent: 4868103 (1989-09-01), Stavrianopoulos et al.
patent: 4873633 (1989-10-01), Mezei et al.
patent: 4874948 (1989-10-01), Cielo et al.
patent: 4883579 (1989-11-01), Humphries et al.
patent: 4892409 (1990-01-01), Smith
patent: 4894347 (1990-01-01), Hillyard et al.
patent: 4931402 (1990-06-01), Abplanalp
patent: 4936682 (1990-06-01), Hoyt
patent: 4948442 (1990-08-01), Manns
patent: 4968148 (1990-11-01), Chow et al.
patent: 4979093 (1990-12-01), Laine et al.
patent: 4979821 (1990-12-01), Schutt et al.
patent: 5002889 (1991-03-01), Klein
patent: 5017019 (1991-05-01), Pompei
patent: 5047215 (1991-09-01), Manns
patent: 5056525 (1991-10-01), Hafezi
patent: 5084246 (1992-01-01), Lyman et al.
patent: 5086002 (1992-02-01), Hillyard et al.
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5110556 (1992-05-01), Lyman et al.
patent: 5112134 (1992-05-01), Chow et al.
patent: 5169601 (1992-12-01), Ohta et al.
patent: 5178019 (1993-01-01), Keiter
patent: 5198670 (1993-03-01), VanCauter et al.
patent: 5199436 (1993-04-01), Pompei et al.
patent: 5204268 (1993-04-01), Matsumoto
patent: 5206568 (1993-04-01), Bjornson et al.
patent: 5207987 (1993-05-01), Kureshy et al.
patent: 5208161 (1993-05-01), Saunders et al.
patent: 5216488 (1993-06-01), Tuunanen et al.
patent: 5225164 (1993-07-01), Astle
patent: 5262128 (1993-11-01), Leighton et al.
patent: 5273718 (1993-12-01), Sköld et al.
patent: 5275951 (1994-01-01), Chow et al.
patent: 5287758 (1994-02-01), Geiss et al.
patent: 5296195 (1994-03-01), Pang et al.
patent: 5307144 (1994-04-01), Hiroshi et al.
patent: 5319436 (1994-06-01), Manns et al.
patent: 5340747 (1994-08-01), Eden
patent: 5341215 (1994-08-01), Seher
patent: 5349436 (1994-09-01), Fisch
patent: 5355215 (1994-10-01), Schroeder et al.
patent: 5376335 (1994-12-01), Gleaves
patent: 5381796 (1995-01-01), Pompei
patent: 5384093 (1995-01-01), Ootani et al.
patent: 5386831 (1995-02-01), Gluck
patent: 5401465 (1995-03-01), Smethers et al.
patent: 5436718 (1995-07-01), Fernandes et al.
patent: 5443791 (1995-08-01), Cathcart et al.
patent: 5445157 (1995-08-01), Adachi et al.
patent: 5445158 (1995-08-01), Pompei
patent: 5449921 (1995-09-01), Baba
patent: 5457527 (1995-10-01), Manns et al.
patent: 5459300 (1995-10-01), Kasman
patent: 5469855 (1995-11-01), Pompei et al.
patent: 5487872 (1996-01-01), Hafeman et al.
patent: 5497670 (1996-03-01), Carl
patent: 5508197 (1996-04-01), Hansen et
Hopkins John M.
Neilson Andy C.
Orrell, III James D.
Oster Michael W.
Samson Marc
FLIR Systems Boston, Inc.
Kolisch & Hartwell, P.C.
Snay Jeffrey R.
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