Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Wearing apparel – fabric – or cloth
Patent
1995-07-28
1997-08-19
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Wearing apparel, fabric, or cloth
424443, 424447, 424448, 424449, 514817, 514937, 514944, 602 41, 602 46, A01N 2534
Patent
active
056585837
ABSTRACT:
An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.
REFERENCES:
patent: 3929131 (1975-12-01), Hardwick
patent: 4230105 (1980-10-01), Harwood
patent: 4286592 (1981-09-01), Chandrasekaran
patent: 4529601 (1985-07-01), Broberg et al.
patent: 4685911 (1987-08-01), Konno et al.
patent: 4693706 (1987-09-01), Ennis, III
patent: 4747841 (1988-05-01), Kuratomi et al.
patent: 4830855 (1989-05-01), Stewart
patent: 4898592 (1990-02-01), Latzke et al.
patent: 4911707 (1990-03-01), Heiber et al.
patent: 4913957 (1990-04-01), Strack et al.
patent: 4994049 (1991-02-01), Latzke et al.
patent: 5108710 (1992-04-01), Little et al.
patent: 5114411 (1992-05-01), Haber et al.
patent: 5128137 (1992-07-01), Muller et al.
patent: 5147339 (1992-09-01), Sundstrom
patent: 5213129 (1993-05-01), Someah et al.
patent: 5217718 (1993-06-01), Colley et al.
patent: 5229133 (1993-07-01), Wright et al.
patent: 5276032 (1994-01-01), King et al.
patent: 5279594 (1994-01-01), Jackson
patent: 5329976 (1994-07-01), Haber et al.
patent: 5330452 (1994-07-01), Zook
patent: 5364350 (1994-11-01), Dittman
Mack Publishing Company, "Stability of Pharmaceutical Products", Pharmaceutical Sciences, pp. 1481-1482, 1985.
McCafferty, et al., "Comparative In Vivo Assessment of the Percutaneous Absorption of Local Anaesthetics", Br. J. Anaesth., vol. 60, (1988), pp. 64-69.
Woolfson, et al., "Concentration Response Analysis of Percutaneous Local Anaesthetic Formulations ", Br. J. Anaesth., vol. 61, (1988), pp. 590-592.
McCafferty, et al., "In Vivo Assessment of Percutaneous Local Anaesthetic Preparations", Br. J. Anaesth., vol. 62, (1989), pp. 18-21.
Knutson, et al., "Solvent-Mediated Alterations of the Stratum Corneum",Journal of Controlled Release, vol. 11, (1990), pp. 93-103.
Lycka, "EMLA, A New and Effective Topical Anesthetic", J. Dermotol. Surg. Oncol., 18:859-862 (1992).
McCafferty, et al., "New Patch Delivery System for Percutaneous Local Anaesthesia", Br. J. Anaesth., 71:370-374 (1993).
Sakamoto, et al., "Dermal Patch Anaesthesia: Comparison of 10% Lignocaine Gel with Absorption Promoter and EMLA Cream", Anaesthesia, vol. 48, (1993), pp. 390-392.
Woolfson, Percutaneous Local Anaesthesia, (1993), pp. 166-170.
Astra USA, Inc., "EMLA Cream Product Information Form For American Hospital Formulary Service", 1993, pp. 1-28.
Zhang Hao
Zhang Jie
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