Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Reexamination Certificate
2005-07-05
2005-07-05
Noguerola, Alex (Department: 1753)
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
C204S601000, C422S070000, C422S091000
Reexamination Certificate
active
06913679
ABSTRACT:
Sample component separation apparatus and methods are described. An exemplary sample component separation apparatus includes a separation channel having a turn portion configured to reduce band-broadening caused by passage of a sample through the turn portion. To reduce band broadening caused by passage of a sample through a turn portion, the turn portion may be constructed and arranged to have a sample transport characteristic that is different from the corresponding sample transport characteristic of a substantially straight portion of the separation channel. For example, the turn portion may be configured with an effective channel width that is smaller than the effective channel widths of the substantially straight portion of the separation channel. The actual channel width of the turn portion may be smaller than the channel widths of the substantially straight portion; the effective channel width of the turn portion may be reduced by placing one or more sample transport barriers or constrictions in the turn portion of the channel. Alternatively, the sample velocity through the turn portion may be controlled so as to reduce band broadening. For example, sample transport barriers may be disposed in the turn portion so that sample components of a given band travel through the turn portion at substantially the same effective rate, whereby the band orientation remains substantially aligned along radial directions characteristic of the turn portion. Other a sample transport characteristics, such as electrical resistance or fluid flow resistance, of the turn portion may be adapted to reduce band broadening caused by passage of the sample through the turn portion.
REFERENCES:
patent: 4551251 (1985-11-01), Kolobow et al.
patent: 4868129 (1989-09-01), Gibbons et al.
patent: 5061361 (1991-10-01), Gordon
patent: 5194133 (1993-03-01), Clark et al.
patent: 5324413 (1994-06-01), Gordon
patent: 5439578 (1995-08-01), Dovichi
patent: 5498324 (1996-03-01), Yeung
patent: 5512158 (1996-04-01), Cole
patent: 5730850 (1998-03-01), Kambara et al.
patent: 5804022 (1998-09-01), Kaltenbach et al.
patent: 5833827 (1998-11-01), Anazawa et al.
patent: 6186660 (2001-02-01), Kopf-Sill
patent: WO99/24828 (1999-05-01), None
patent: 0386925 (1990-09-01), None
patent: 2128099 (1984-04-01), None
patent: WO 96 04547 (1996-02-01), None
patent: 9822811 (1998-05-01), None
patent: WO 9924828 (1999-05-01), None
Koo et al. “Liquid flow in microchannels: experimental observations and computational analyses of microfluidics effects,” J. Micromech. Microeng. 13 (2003) 568-579.
C. Alexay et al., “Fluorescence scanner employing a Macro Scanning Objective,”SPIEvol. 2705, 4/1996, pp. 63-72, month unknown.
Bartosiewicz et al., “Implementation of a capillary array electrophoresis instrument,”ISC Technical Publications, Inc.2/96, pp. 61-68, month unknown.
Chee et al., “Accessing Genetic Information with High-Density DNA Arrays,”Sciencevol. 274, Oct. 25, 1996, pp. 610-614.
Clark et al., High-Speed Parallel Separation of DNA Restriction Fragments Using Capillary Array Electrophoresis,Anal. Biochemistry 215, 1993, pp. 163-170, month unknown.
Clark et al., “Multiplex dsDNA Fragment Sizing Using Dimeric Intercalation Dyes and Capillary Array Electrophoresis:Ionic Effects on the Stability and Electophoretic Mobility of DNA-Dye Complexes,”Analytical Chemistry, vol. 69, No. 7, pp. 1355-1363, Apr. 1, 1997.
Cohen et al., “Separation and analysis of DNA sequence reaction products by capillary gel electrophoresis,”Journal of Chromatography, 516, 1990, pp. 49-60, month unknown.
Drossman et al., “High-Speed Separations of DNA Sequencing Reactions by Capillary Electrophoresis,”Anal. Chem.vol. 62, 1990, pp. 900-903, month unkown.
Effenhauser et al., “Glass Chips for High-Speed Capillary Electrophoresis Separations with Submicrometer Plate Heights,”Anal. Chem., vol. 65, 1993, pp. 2637-2642, Oct.
Effenhauser et al., “High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device,”Anal. Chem.vol.66, 1994, pp. 2949-2953, Sep.
Feder et al., “A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis,”Nature genetics, vol.13, 8/1996, pp. 399-408, month unknown.
Glazer et al., “Energy-transfer fluorescent reagents for DNA analyses,”Anal. Biotech., 1997, pp. 94-102.
Harrison et al., “Capillary Electrophoresis and Sample Injection Systems Integrated on a Planar Glass Chip,”Anal. Chem., vol. 64, 1992, pp. 1926-1932, Sep.
Harrison et al., “Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip,”Science, vol. 261, Aug. 13, 1993, pp. 895-897.
S. Hjerten, “High-Performance Electrophoresis Elimination of Electroendosmosis and Solute Adsorption,”Journal of chromatography, 347, 1985, pp. 191-198, month unknown.
Huang et al., “Capillary Array Electrophoresis Using Laser-Excited Confocal Fluorescence Detection,”Anal. Chem.vol. 64, 1992, pp. 968-972, Apr.
Huang et al., “DNA Sequencing Using Capillary Array Electrophoresis,”Anal. Chem., vol. 64, 1992, pp. 2149-2154, Sep.
Jacobson et al., “Microchip Capillary Elelctrophoresis with an Integrated Postcolumn Reactor,”Anal. Chem., vol.66, 1994, pp. 3472-3476, Oct.
Jacobson et al., “Integrated Microdevice for DNA Restriction Fragment Analysis,”Anal. Chem., vol. 68, 1996, pp. 720-723, month unknown.
Kheterpal et al., “DNA sequencing using a four-color confocal fluorescence capillary array scanner,”Electrophoresis, vol.17, 1996, pp. 1852-1859, month unknown.
Kostichka et al., “High speed automated DNA sequencing in ultrathin slab gels.”Biotechnology, vol. 10, 1/92, pp. 78-81, Jan.
Landers et al., “Capillary Electrophoresis: A Powerful Microanalytical Technique for Biologically Active Molecules,”Biotechniques, vol.14,no.1, 1993, pp. 98-111.
Li et al., “Transport, Manipulation, and Reaction of Biological Cells On-Chip Using Electrokinetic Effects,”Anal. Chem., vol.69, 1997, pp. 1564-1568, Apr.
Manz et al., “Capillary electrophoresis on a chip,”Journal of Chromatography, 593, 1992, pp. 253-258, month unknown.
Merryweather et al., “Global prevalence of putative haemochromatosis mutations,”Med Genet,1997, pp. 275-278, Jan.
Miller et al., “A simple salting out procedure for extracting DNA from human nucleated cells,”Nucleic Acids Research, vol.16, No.3, 1988, p. 1215, month uknown.
Scriver, M.D. et al., “The metabolic and molecular bases of inherited disease,” Chemochromatosis, chapter 69, 1995, pp. 2237-2269, month unknown.
G.F. Sensabaugh, “Commentary,”Blood Cells, Molecules, and Diseases, 22, Aug. 31, 1996, pp. 194a-194b.
Simpson et al., “Microfabrication Technology for the Production of Capillary Array Electrophoresis Chips,” Department of Chemistry, University of CA, Berkeley, pp. 15.
Simpson et al., “High-throughput genetic analysis using microfabricated 96-sample capillary array electrophoresis microplates,”Proc. Natl. Acad. Sci. USA, vol. 95, pp. 2256-2261, 3/1998, pp. 2256-2261.
Swerdlow et al., “Capillary gel electrophoresis for rapid, high resolution DNA sequencing,”Nucleic Acids Research, vol. 18, no.6, 1990 Oxford University Press, pp. 1415-1419, month unknown.
Takahashi et al., “Multiple Sheath-Flow Gel Capillary-Array Electrophoresis for Multicolor Fluorescent DNA Detection,”Anal. Chem.1994, 66, pp. 1021-1026, Apr.
Ueno et al., “Simultaneous Monitoring of DNA Fragments Separated by Electrophoresis in a Multiplexed Array of 100 Capillaries,”Anal. Chem. 66, 1994, pp. 1424-1431, May.
Wang et al., “High-resolution capillary array electrophoretic sizing of multiplexed short tandem repeat loci using energy-transfer fluorescent primers,”Electrophoresis, 17,
Hutt Lester
Mathies Richard A.
Paegel Brian
Simpson Peter C.
Beyer Weaver & Thomas LLP.
Noguerola Alex
The Regents of the University of California
LandOfFree
Apparatus and methods for high resolution separation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus and methods for high resolution separation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and methods for high resolution separation of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3373374