Apparatus and methods for controlling fluid flow in microchannel

Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus

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417 48, 417 49, 417 50, 417 53, B01D 6142, F04F 1100

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056328761

ABSTRACT:
By combining electro-osmotic and electrohydrodynamic pumps in a microchannel, both polar and non-polar fluids can be moved along said channel. The pumps can be made from pairs of wire electrodes inserted into openings in the channel and connected to a source of a pulsed DC power. By reversing the voltages on alternate pairs of pumps, fluid flow can be reversed, thereby acting as a gate or valve. By using digital drivers, for example shift registers that can apply a signal to a switching device connected to an electrode by means of enabling and latch signals to an AND gate, control of flow in individual channels in an array of channels can be had with a high degree of integration, and provide for ready manufacturability.

REFERENCES:
patent: 4412785 (1983-11-01), Roman
patent: 4676274 (1987-06-01), Brown
patent: 4891120 (1990-01-01), Sethi et al.
patent: 4908112 (1990-03-01), Pace
patent: 5003822 (1991-04-01), Joshi
patent: 5006749 (1991-04-01), White
patent: 5141868 (1992-08-01), Shanks et al.
patent: 5180288 (1993-01-01), Richter et al.
patent: 5194133 (1993-03-01), Clark et al.
patent: 5250263 (1993-10-01), Manz
patent: 5296114 (1994-03-01), Manz
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5480614 (1996-01-01), Kamahori
Dasgupta et al, "Electroosmosis: A reliable Fluid Propulsion System for Flow Injection Analysis", Anal. Chem. vol. 66, No. 11, Jun. 1, 1994, pp. 1792-1798.
Stuetzer, "Ion Drag Pumps", J. Appl. Physics, vol. 31 No. 1, Jan., 1960, pp. 136-146.
Pickard, "Ion Drag Pumping. I. Theory", J. Appl. Physics, vol. 34 No. 2, Feb. 1963, pp. 246-250.
Pickard, "Ion Drag Pumping. II. Experiment", J. Appl. Physics, vol. 34 No. 3, Feb. 1963, pp. 251-258.
Melcher, "Traveling-Wave Induced Electroconvection", The Physics of Fluids, vol. 9 No. 8, Aug. 1966, pp. 1548-1555.
Bart et al, "Microfabricated Electrohydrodynamic Pumps", Sensors and Actuators, A21-A23 (1990) pp. 193-197 no month provided.
Woolley et al. Ultra-High-Speed DNA Fragment Separations using Microfabricated Capillary Array Electrophoresis Chips, Proc. Natl. Acad. Sci. USA 91:11348-11352, Nov. 1994.
Harmon et al., Selectivity in Electrophoretically Mediated Microanalysis by Control of Product Detection Time, Anal. Chem. 66:3797-3805, 1994 no month.
Patterson, et al., Electrophoretically Mediated Microanalysis of Calcium, Journal of Chromatography A, 662:389-395, 1994 no month.
Microfabricated Device is Chemistry Lab on a Chip, Chemical & Engineering News, (no date).
Harmon et al., Mathematical Treatment of Electrophoretically Mediated Microanalysis, Anal. Chem. 65:2655-2662, 1993 no month.
Avila and Whitesides, Catalytic Activity of Native Enzymes During Capillary Electrophoresis: An Enzymatic Microreactor, J. Org. Chem. 58:5508-5512, 1993.
Harmon, et al., Electrophoretically Mediated Microanalysis of Ethanol, J. Chromatog. A, 657:429-434, 1993 no month.
Bao and Regnier, Ultramicro Enzyme Assays in a Capillary Electrophoretic System, J. Chrom. 608:217-224, 1992 no month.
Richeter et al., A Micromachined Electrohydrodynamic (EHD) Pump, Sensors and Actuators A, 29:159-168, 1992 no month.
Tracey, et al., Microfabricated Microhaemorheometer, pp. 82-84, 1991 no month.
Jacobson et al., Precolumn Reactions with Electrophoretic Analysis Integrated on a Microchip, Anal, Chem., 66:4127-4123, 1994 no month.
Jacobson, et al., Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices, Anal. Chem. 1994, 66:1107-1113 no month.
Jacobson, et al., High-Speed Separatioins on a Microchip, anal. Chem. 1994, 66:1114-1118 no month.
Fan, et al., Micromachining of Capillary Electrophoresis Injectors and Separators on Glass Chips and Evaluation of Flow at Capillary Intersections, Anal. Chem., 1994, 6:177-184 no month.
Megregany, Microelectromechnical Systems, Circuits and Devices, Jul. 1993.
Harrison, et al., Micromachining a Minaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip, Science, vol. 261, Aug. 13, 1993.
Harrison, et al., Capillary Electrophoresis and Sample Injection Systems Integrated on a Planar Glass Chip, Anal. Chem. 1992, 64:1926-1932 no month.
Fisher, Microchips for Drug Compounds, New York times, Mar. 3, 1991.
Fodor, ete al., Light-Directed, Spatially Addressable Parallel Chemical Synthesis, Research Article, Science, vol. 251, Feb. 15, 1991, pp. 767-773.
The Silver Shotguns, The Economist, Dec. 14-20, 1991.
Howe, et al., Silicon Micromechanics; Sensors and Actuators on a Chip, IEEE Spectrum, Jul. 1990.
Wenzel, et al., A Multisensor Employing an Ultrasonic Lamb-Wave Oscillator, IEEE Transactions on Electron Devices, vol. 35, No. 5, Jun. 1988.
Angell, et al., Silicon Micromechanical Devices, Scientifid American 248:44-55, 1983.
Petersen, Silicon as a Mechanical Material, Proceedings of the IEEE, vol. 79, No. 5, May 1982.
Andreas Manz et al., Trends in Analytical Chemistry, 10(5):144-148 (1991) (no month).

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