Surgery – Truss – Pad
Patent
1995-06-07
1998-01-13
Smith, Ruth S.
Surgery
Truss
Pad
1286534, A61B 514
Patent
active
057068054
ABSTRACT:
The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological system and exposed to a magnetic field and an electromagnetic field in the 1-2 GHz range. The EPR spectra is then measured at the biological system to determine oxygen concentration. The EPR spectra is determined by an EPR spectrometer that adjusts the resonator to a single resonator frequency to compensate for movements of the biological system, such as a human or animal. The biological system can also include other in vivo tissues, cells, and cell cultures to directly measure pO.sub.2 non-destructively. The paramagnetic material can be used non-invasively or invasively depending on the goals of the pO2 measurement. A detecting inductive element, as part of the EPR spectrometer resonator, is adapted relative to the measurement particularities.
REFERENCES:
patent: 4560663 (1985-12-01), Nicksic et al.
patent: 4593248 (1986-06-01), Hyde et al.
patent: 4714886 (1987-12-01), Halpern
patent: 4803124 (1989-02-01), Pilbrow et al.
patent: 5204628 (1993-04-01), Kunishi et al.
patent: 5233303 (1993-08-01), Bales et al.
Crepeau et al., "Communications--Composite Pulses in Time-Domain ESR", J. of Magnetic Resonance Imaging, vol. 84, pp. 184-190 (Aug. 1989).
Glockner et al., "In Vivo Oximetry Using a Nitroxide-Liposome System," J. of Magnetic Resonance, vol. 20, pp. 123-133 (Jul. 1991).
Duret et al., "Oxygen concentration measurements using the ESR line modification of PcLi molecules" Sensors and Actuators B Chemical, vol. B6, pp. 269-269 (Jan. 1992).
JD. Chapman, "Measurements of tumor hypoxia by invasive and non-invasive procedures: a review of recent clinical studies," Radiotherapy and Oncology, pp. 13-19, Suppl. 20 (1991).
Smirnov et al., "Simultaneous Multi-Site EPR Spectroscopy in Vivo," Magnetic Residence in Medicine, vol. 30, pp. 213-220 (Aug. 1993).
Swartz et al., "India Ink: a potential clinically applicable EPR oximetry probe,"Magnetic Resonance in Medicine, vol. 31, pp. 229-232 (Feb. 1994).
Swartz et al., "Measurements of Pertinent Concentrations of Oxygen in Vivo," Magnetic Resonance in Medicine, vol. 20, No. 2, pp. 333-339 (Aug. 1991).
K.J. Liu et al., "Lithium phthalocyanine: a probe for electron paramagnetic resonance oximetry in viable biological systems," Proceedings of the National Academy of Sciences, pp. 5438-5442, vol. 90, No. 12 (Jun. 1993).
J.M. Vanderkooi et al., "Oxygen in mammalian tissue: methods of measurement and affinities of various reactions," American Journal of Physiology, pp. C1131-C1150, vol. 260, No. 6 (Jun. 19).
James Glockner et al., "In vivo EPR oximetry using two novel probes: fusinite and lithium phthalocyanine," Oxygen Transport to Tissue XIV, pp. 229-234, Plenum Press, New York (1992).
Ernst Epstein, "Surgical Gem," The Journal of Dermatalogical Surgery and Oncology, pp. 273-274, vol. 15, No. 3 (Mar. 1989).
H.M. Swartz et al., "The use of EPR for the measurement of the concentration of oxygen in vivo tissues under physiological pertinent conditions and concentrations," The Journal of Dermatological Surgery and Oncology, pp. 221-228, vol. 15, No. 3 (Mar. 1989).
Arie H. Bartel et al., "Malignant melanoma arising at tattoo sites used for radiotherapy field marking," The British Journal of Radiology, pp. 913-914, vol. 53, No. 633 (Sep. 1980).
M. Brian Fennerty et al., "Effectiveness of India ink as a long-term colonic mucosal marker," The American Journal of Gastroenterology, pp. 79-81, vol., 87, No. 1 (Jan. 1992).
William J. Whalen et al., "Skeletal Muscle PO2 effect of inhaled and topically applied O2 and CO2," American Journal of Physiology, pp. 973-980.
Thomas E. J. Gayeski et al., "Intracellular PO2 in long axis of individual fibers in working dog gracilis muscle," The American Journal of Physiology, pp. H1179-H1186.
Goda Fuminori
Liu Ke Jian
Mader Karsten
Swartz Harold M.
Walczak Tadeusz
Smith Ruth S.
Trustees of Dartmouth College
Vock Curtis A.
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