Apparatus and method of use for a photosensitizer enhanced fluor

Details Apparatus and method of use for a photosensitizer enhanced fluor Apparatus and method of use for a photosensitizer enhanced fluor

1991-04-03

1994-06-07

Green, Randall L.

Surgery

Truss

Pad

128634, 128664, 128665, 606 2, 606 13, 606 14, 606 15, A61B 500

Patent

active

053180232

ABSTRACT:
A method and apparatus is disclosed for the instant intraoperative detection and biopsy of metastatic cancer using fluorescence spectroscopy. A photosensitizing agent selectively retained by cancerous tissue is administered prior to surgery. A fiberoptic probe integrated with a biopsy device illuminates the examined tissue and causes fluorescence which is recorded by a spectrograph and plotted as a spectral curve. The intensity ratio (S1/S2) for the fluorescence from the photosensitizing agent (S1) and autofluorescence (S2) for the examined tissue is compared with the intensity ratio at the same wavelengths for primary tumor and normal tissue. Tissue that displays an intensity ratio different from that of normal tissue can immediately be analyzed for the depth of tumor involvement and then excised for histological examination using the biopsy device.

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