Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2006-06-06
2006-06-06
Kam, Chih-Min (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S013000, C435S262000, C435S283100, C435S002000, C422S105000, C604S005010, C604S246000
Reexamination Certificate
active
07056722
ABSTRACT:
A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
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Brausch Jim
Coelho Philip Henry
Godsey James H.
Kingsley Phil
Rock Gail
Bernhard Kreten
Kam Chih-Min
Millemann Audrey A.
ThermoGenesis Corp.
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