Apparatus and method of detection employing an AC frequency sens

Details Apparatus and method of detection employing an AC frequency sens Apparatus and method of detection employing an AC frequency sens

1996-08-29

1999-01-12

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 435 16, 435 71, 435 79, 4352871, 4352872, 204400, 204403, 436527, C12Q 168, G01N 2726, G01N 3353, G01N 33552

Patent

active

058586660

ABSTRACT:
A transducer for detecting biomolecules comprises a bottom and a top unit. The bottom unit has a set of parallel electrically conductive transmission lines thereon and probes attached to selected locations along each transmission line for binding with the target molecule. The top unit has thereon a second set of parallel transmission lines transverse to those on the bottom unit. By applying AC signals sequentially to the two sets of transmission lines, each of the probe locations at the intersection of the two transmission lines can be addressed and the response of the probe in an unfilled detector location or a complex formed by the probe and the target in a filled detector location can be measured. If the target has been labelled, than the label at each of the locations may also be detected. The device can also be used for measuring binding constants between the probe and the target and concentrations of target solutions.

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International Search Report by the European Patent Office mailed Dec. 4, 1997.

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