Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Sample mechanical transport means in or for automated...
Reexamination Certificate
2005-07-12
2005-07-12
Warden, Jill (Department: 1743)
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Sample mechanical transport means in or for automated...
C422S063000, C422S065000, C422S067000, C422S091000, C422S105000, C436S044000, C436S046000, C436S174000, C436S180000
Reexamination Certificate
active
06916447
ABSTRACT:
The present invention provides a method and apparatus for dispensing small volumes of selected substances, such as biological reagents or samples, onto substrates. According to one general embodiment, a plurality of spaced, tandemly-arranged substrates are advanced, e.g., by way of a conveyor, along a transport pathway extending over a reagent-supply location, such as a reservoir supported at a fixed position in a base. From a position over the reagent-supply location and the pathway, a reagent-transfer instrument, or tip, is extended along an axis through an intervening region, e.g., an opening defined by a surface of the conveyor, separating an adjacent pair of advancing substrates to contact reagent held at the reagent-supply location. The reagent-transfer instrument is then withdrawn, along with a portion of such reagent, through the intervening region to a position above the transport pathway. Once the conveyor has advanced a selected substrate, upstream of the intervening region, to a position aligned with the axis of the reagent-transfer instrument, a selected amount of reagent is transferred from the instrument onto a selected site of the substrate. Advantageously, the apparatus and method are readily adaptable for the production of micro-arrays having a great number of closely spaced spots.
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Applera Corporation
Frazier Jeffrey D.
Handy Dwayne K
Warden Jill
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