Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory...
Reexamination Certificate
2006-05-30
2006-05-30
Le, Long V. (Department: 1641)
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
C422S051000, C422S051000, C436S501000, C436S524000, C436S527000, C436S533000, C435S007210, C435S007500, C435S007600, C435S007900, C536S023100, C356S302000, C356S305000, C356S330000, C356S904000, C356S929000, C356S958000, C251S315040, C251S315040, C251S315040, C251S315040
Reexamination Certificate
active
07052650
ABSTRACT:
Apparatus for the manipulating and testing of molecules and in particular of DNA comprising a surface on which the molecule is anchored on multiple points at one end and a paramagnetic bead on which said molecule is anchored on multiple points at its other end, magnetic means for applying a force to the bead, said magnetic means being used to control the stretching and rotation of said bead and molecule, optical magnification means and a camera for the visualisation of said bead, computer means to which the images of the camera are transmitted, said computer means comprising means for analyzing the motions of the bead. A method for the manipulating and testing of molecules and in particular of DNA in which a molecule is anchored at one end to a fixed surface and at its other end to a paramagnetic bead wherein said molecule is anchored on multiple points at each of said ends.
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P. Cluzel, et al., “DNA: An Extensible Molecule”,Science, 271, No. 5250, (1996), pp. 792-794.
S.B. Smith, et al., “Overstretching B-DNA: The Elastic Response of Individual Double-Stranded and Single-Stranded DNA Molecules,”Science, 271, No. 5250, (1996), pp. 795-799.
S.B. Smith, et al., “Direct Mechanical Measurements of the Elasticity of Single DNA Molecules by Using Magnetic Beads,”Science, 258, No. 5085, (1992), pp. 1122-1126.
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Allemand Jean F.
Bensimon Aaron
Bensimon David
Croquette Vincent
Strick Terrence R.
Center National de la Recherche Scientifique (CNRS)
Do Pensee T.
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Le Long V.
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