Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-07-20
1997-06-10
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 436527, 436164, 436149, 436807, 422 55, 422 57, 422 8201, 422 8205, 356318, 356244, C12Q 168
Patent
active
056374585
ABSTRACT:
A system for biomolecular separation and detection of a molecular species includes a solid state laser detector having a sample channel therein. The presence of a molecular species is indicated by a frequency shift in the laser's output, which is detected by optical heterodyning the laser's output with the output of a reference laser. The interior of the sample channel is optionally coated with a ligand for binding the molecular species of interest. The system involves preprocessing a sample by electroosmotic separation in channels that are lithographically formed in a two-dimensional planar substrate. Molecular separation is also accomplished in a nanostructural molecular sieve comprising spaced apart posts defining narrow channels therebetween.
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Forsyth James M.
Frankel Robert
Freed Rachel Heather
Hutzell Paula K.
Sios, Inc.
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