Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2006-08-17
2010-06-08
Clow, Lori A (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C702S027000, C703S011000
Reexamination Certificate
active
07734425
ABSTRACT:
Provided are an apparatus and method of searching a protein active site. The apparatus includes a database which stores information on a plurality of reference active sites, a comparing unit which calculates 3D structural similarities according to the number of overlapping residues, with respect to an input active site and the stored reference active site, and a search unit which searches the reference active site with respect to the input active site according to the similarities. Accordingly, similar active sites can be searched with a low computational complexity, thereby be used for a correct new drug design.
REFERENCES:
patent: 2003/0096307 (2003-05-01), Fetrow
patent: 1020050046960 (2005-05-01), None
patent: 1020050064644 (2005-06-01), None
Holm et al. (Proceedings of International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology 1995;3():179-87).
Liisa Holm et al.; “Protein Structure Comparison by Alignment of Distance Matrices”; J.Mol. Biol. (1993) 233; pp. 123-138.
Shann-Ching Chen et al.; “Protein Retrieval by Matching 3D Surfaces”; pp. 1-4, 2002.
Kim Dae Hee
Park Chan Yong
Park Seon Hee
Park Sung Hee
Clow Lori A
Electronics and Telecommunications Research Institute
Lowe Hauptman & Ham & Berner, LLP
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