Apparatus and method for screening, olfactory mucosa...

Details Apparatus and method for screening, olfactory mucosa... Apparatus and method for screening, olfactory mucosa...

2006-02-07

2006-02-07

Hindenburg, Max F. (Department: 1645)

Surgery

Diagnostic testing

Olfactometer

C600S300000, C604S019000, C604S048000

Reexamination Certificate

active

06994671

ABSTRACT:
A method and apparatus for readily and reliably screening olfactory mucosa stimulating compounds are provided. An olfactory mucosa stimulating compound is sprayed through an atomizing nozzle33to an olfactory mucosa of a rat fixed in a test animal fixing device32. A measuring electrode portion10is implanted in an olfactory bulb of the rat for measuring an electrical signal generated in the olfactory bulb. Efficacy of the olfactory mucosa stimulating compound is determined based on a correlation between an electrical signal measured by the measuring electrode portion10when the olfactory mucosa stimulating compound is sprayed on the olfactory mucosa of the rat and a physiological response induced in the rat.

REFERENCES:
patent: 3885550 (1975-05-01), MacLeod
patent: 6678553 (2004-01-01), Lerner et al.
patent: 0 970 702 (2000-01-01), None
patent: 11-196870 (1999-07-01), None

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