Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2008-07-15
2011-12-13
Wax, Robert A (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C514S475000, C514S563000, C514S473000, C514S291000, C424S489000
Reexamination Certificate
active
08075908
ABSTRACT:
A method for inhibiting formation of adhesions following abdominal surgery which involves application of an anti-static fatty acid ethoxylated amide (Cocamide DEA) in a matrix that is placed in the peritoneal cavity at the conclusion of an abdominal surgery and which releases this anti-adhesive chemical over a predetermined time in a range from about five to seven days. Tests conducted on laboratory rats established that the method reduced the incidences of adhesions from 100 percent (100%) in a test model to near zero percent (0%) in the treated animals. In an alternative embodiment, Andrographalide was delivered through a drug pump with similar results. In still another embodiment, an effective amount of Rapamune was delivered, via a pump, into the abdominal cavity, again with similar results.
REFERENCES:
patent: 2004/0087613 (2004-05-01), Molmenti
patent: 2005/0181023 (2005-08-01), Young et al.
patent: WO 2005/079704 (2005-09-01), None
patent: WO 2006/014534 (2006-02-01), None
Hardin, Eugene, et al., eMedicine Consumer Journal, Apr. 30, 2002, vol. 3, No. 4, Copyright 2002, eMedicine.com, Inc.
Xia, Yi-Feng, et al., “Andrographolide Attentuates Inflammation by Inhibition of NF-kB Activation through Covalent Modification of Reduced Cysteine 62 of p50”, The Journal of Immunology, pp. 4208-4217, Copyright 2004 by The American Associates of Immunologist, Inc.
Hidalgo, M.A., et al., “Andrographolide Interferes with Binding of Nuclear Factor-xB to DNA in HL-60-Derived Neutrophilic Cells”, The British Journal of Pharmacology, 2005 (vol. 144) (No. 5) pp. 680-686, Nature Publishing Group.
Angiotech Pharmaceuticals, Inc. Presents Positive Adhibit(TM) Data at the 19th Annual European Congress of Obstetrics and Gynecology, Apr. 7, 2006. www.biospace.com.
Journal of the National Cancer Institute, vol. 93, No. 20, Oct. 17, 2001, “Rapamycin's Resurrection: A New Way to Target the Cancer Cell Cycle”.
“Angiotech-Redefining Success—Surgical Adhesions”, Copyright 2006, www.angiotech.com.
“Introduction—Rapamycin”, www.ch.ic.ac.uk.
“Sirolimus” From Wikipedia, en.wikipedia.org.
Al-Awadi Danah
Anhese LLC
Nikolai Thomas J.
Nikolai & Mersereau , P.A.
Wax Robert A
LandOfFree
Apparatus and method for reducing the occurrence of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus and method for reducing the occurrence of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for reducing the occurrence of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4271543