Apparatus and method for reading fluorescence from bead arrays

Details Apparatus and method for reading fluorescence from bead arrays Apparatus and method for reading fluorescence from bead arrays

2006-05-25

2010-06-08

Shibuya, Mark L (Department: 1641)

Chemistry: analytical and immunological testing

Optical result

With fluorescence or luminescence

C356S319000, C356S123000, C356S126000, C359S196100, C388S931000

Reexamination Certificate

active

07732217

ABSTRACT:
When detecting fluorescence of a bead chip array, reflected light from a bead is detected at the same time, so as to recognize the bead position. The reflected light can be detected in a similar manner for all beads, regardless of the presence or absence of a fluorescent substance. If the positions of all beads are detected, accurate detection can be achieved by quantifying only the fluorescence at the detected positions. The fluorescence wavelength alone is detected by a first detector using a wavelength selection filter. Other wavelengths are detected by a second detector, thereby obtaining the reflected light. Data on the reflected light is processed into an image for obtaining the bead profile, the bead position is recognized by detecting the center position based on the profile, and the fluorescence is quantified based on the bead position.

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