Apparatus and method for rapid on-line electrochemistry and mass

Details Apparatus and method for rapid on-line electrochemistry and mass Apparatus and method for rapid on-line electrochemistry and mass

1996-11-15

1999-03-09

Soderquist, Arlen

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

250288, 422 8201, 422100, 436139, 436140, G01N 2400, B01D 5944, H01J 4900

Patent

active

058799494

ABSTRACT:
An electrochemical cell is coupled on-line with a mass spectrometer to achieve minimal response time in a system called rapid electrochemical-mass spectrometry (EC/MS). Many large, nonpolar compounds that could not be analyzed by prior ES/MS techniques may now be analyzed. Ionic and polar intermediates and products generated by electrochemical reactions may be probed with very short response times prior to their analysis. Ions are generated by electrochemical oxidation or reduction immediately prior to electrospray release, pneumatic nebulization, or outlet heating. The on-line coupling of an electrochemical cell to electrospray mass spectrometry permits the fast identification of ionic intermediates (both radicals and non-radicals), as well as products generated from electrochemical reactions and from ensuing solution-phase reactions. Neutral compounds that are otherwise difficult to analyze by ordinary electrospray mass spectrometry may now be analyzed. Preferred three-electrode cells are disclosed.

REFERENCES:
patent: 5223226 (1993-06-01), Wittmer et al.
K.J. Volk et al, Anal. Chem, 1988, 60, 720-722.
T.A. Getek et al, J. Chromatogr. 1989, 474, 245-256.
H. D. Dewald et al, Electroanalysis 1991, 3, 777-782.
P.A. Limbach et al, Internat. J. Mass Spectrom. Ion Process, 1993, 125, 135-143.
G. Hambitzev et al, Synth. Met. 1993, 55, 1317-1322.
L. Fang et al, Anal. Chem. 1994, 66, 3696-3701.
A. Dupont et al, Tetrahedron Lett. 1994, 35, 6083-6086.
C.E.C.A. Hop et al, J. Am. Soc. Mass Spectrum. 1995, 6, 860-865.

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