Chemistry: molecular biology and microbiology – Apparatus
Reexamination Certificate
2010-11-19
2011-12-27
Forman, Betty (Department: 1634)
Chemistry: molecular biology and microbiology
Apparatus
C435S288300, C435S288500, C536S023100, C536S025300, C422S501000, C422S502000, C422S503000, C422S515000
Reexamination Certificate
active
08084245
ABSTRACT:
A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) having an array of reaction wells (26). A transport mechanism (27) aligns the reaction wells (26) and selected nozzles (22) for deposition of the liquid reagent (24) into selected reaction wells (26). A sliding seal (30) is positioned between the head assembly (21) and the base assembly (25) to form a common chamber (31) enclosing both the reaction well (26) and the nozzles (22) therein. A gas inlet (70) into the common chamber (31), upstream from the nozzles (22), and a gas outlet (71) out of the common chamber (31), downstream from the nozzles (22), sweeps the common chamber (31) of toxic fumes emitted by the reagents. Each reaction well (26) includes an orifice (74) extending into the well (26) which is of a size and dimension to form a capillary liquid seal to retain the reagent solution (76) in the well (26) for polymer chain growth therein. A pressure regulating device (82) is provided for controlling a pressure differential, between a first gas pressure exerted on the reaction well (26) and a second gas pressure exerted on an exit (80) of the orifice, such that upon the pressure differential exceeding a predetermined amount, the reagent solution (76) is expelled from the well (26) through the orifice (74). A method of synthesis of a polymer chain in a synthesis apparatus (20) is also included.
REFERENCES:
patent: 5368823 (1994-11-01), McGraw et al.
patent: 5472672 (1995-12-01), Brennan
patent: 5529756 (1996-06-01), Brennan
patent: 6001311 (1999-12-01), Brennan
patent: 7858364 (2010-12-01), Brennan
patent: WO 92/02303 (1992-02-01), None
Forman Betty
The Board of Trustees of the Leland Stanford Junior University
Woodcock & Washburn LLP
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