Heat exchange – With alarm – indicator – signal – register – recorder – test or... – Remotely controlled inspection means
Patent
1993-02-22
1994-08-02
Wayner, William E.
Heat exchange
With alarm, indicator, signal, register, recorder, test or...
Remotely controlled inspection means
422116, 436 50, 935 87, G01N 3502, G05B 1700
Patent
active
053336755
ABSTRACT:
There is disclosed herein a machine for performing nucleic acid amplification under computer control. The machine utilizes any one of a number of heating and cooling systems under control of a host computer which directs the heating and cooling systems to heat and cool a reaction-chamber-containing heat exchanger at appropriate times in the process. The reaction chambers are pre-loaded with the nucleic acid(s) to be amplified, a thermostable enzyme to catalyze polymerization, specific oligonucleotide primers, and four different nucleotide triphosphates. Also disclosed is the process for the amplification chain reaction implemented by the machine, which utilizes a thermostable enzyme.
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Johnson Larry
Leath Richard A.
Mezei Louis M.
Mullis Kary B.
Wennberg Timothy J.
Hoffmann-La Roche Inc.
Wayner William E.
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