Apparatus and method for parallel flow ion mobility...

Radiant energy – Ionic separation or analysis – With sample supply means

Reexamination Certificate

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C250S287000, C250S281000, C250S297000, C250S283000, C250S3960ML, C250S42300F

Reexamination Certificate

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07838826

ABSTRACT:
Analyte ions entrained in a carrier gas are analyzed by parallel flow ion mobility spectrometry prior to analysis by a mass analyzer. An extended ion funnel is located in the vacuum system of the mass analyzer and has an ion focusing section and an ion mobility analyzing section. The carrier gas together with entrained ions is introduced into the ion focusing section where the ions are focused to the axis of the funnel by applied RF voltages. In the ion mobility section, the action of an RF quadrupolar field, the movement of the carrier gas and axial DC field, separates the ions on the basis of their mobilities. The mobility separated ions are released into the mass analyzer where the ions may be further separated on the basis of mass.

REFERENCES:
patent: 6107628 (2000-08-01), Smith et al.
patent: 6486469 (2002-11-01), Fischer et al.
patent: 7087898 (2006-08-01), Willoughby et al.
patent: 2002/0175278 (2002-11-01), Whitehouse
patent: 2002/0175279 (2002-11-01), Hager
patent: 2006/0108520 (2006-05-01), Park et al.
patent: WO 2004/109741 (2004-12-01), None
Barnett, et al., “Application of ESI-FAIMS-MS to the Analysis of Tryptic Peptides”, J Am Soc Mass Spectrom 2002, 13, 1282-1291, Elsevier Science Inc.
Buryakov, et al., “A New Method of Separation of Multi-Atomic Ions by Mobility at Atmospheric Pressure Using a High-Frequency Amplituded-Asymmetric Strong Electric Field”, Int'l J of Mass Spectrom and Ion Processes, 128 (1993) 143-148, Elsevier Science Publishers B.V.
Ells, et al., “Detection of Chlorinated and Brominated Byproducts of Drinking Water Disinfection Using Electrospray Ionization—High-Field Asymmetric Waveform Ion Mobility Spectrometry-Mass Spectrometry”, Anal. Chem., 1999, vol. 71, No. 20, pp. 4747-4752, American Chemical Society.
Page, et al., “Variable Low-Mass Filtering Using an Electrodynamic Ion Funnel”, J Mass Spectrom 2005, 40 1215-1222, John Wiley & Sons, Ltd.
Gabryelski, et al., “Rapid and Sensitive Differentiation of Anomers, Linkage, and Position Isomers of Disaccharides using high-Field Asymmetric Waverform Ion Mobility Spectrometry (FAIMS)”, Am Soc Mass Spectrom 2003, 14, 265-277, Elsevier Science Inc.
Guevremont, et al., “Comparison of Experimental and Calculated Peak Shapes for Three Cylindrical Geometry FAIMS Prototypes of Differing Electrode Diameters”, Am Soc Mass Spectrom 2005, 16, 349-362, Elsevier Inc.
Reigner, et al., “Qualitative Evaluation of Field Ion Spectrometry for Chemical Warfare Agent Detection”, 45thASMS Conference on Mass Spectrometry and Allied Topics, Jun. 1-5, 1997, Palm Springs, CA, US.
Shvartsburg, et al., “FAIMS Operation for Realistic Gas Flow Profile and Asymmetric Waveforms Including Electronic Noise and Ripple”, Am Soc Mass Spectrom 2005, 16, 1447-1455, Elsevier Inc.
Shvartsburg, et al., “Optimization of the Design and Operation of FAIMS Analyzers”, J Am Soc Mass Spectrom 2005, 16, 2-12, Elsevier Inc.
Srebalus, et al., “Gas-Phase Separations of Electrosprayed Peptide Libraries”, Anal. Chem. 1999, 71, 3918-3927.
Taraszka, et al., “Mapping the Proteome of Drosophila Melanogaster: Analysi of Embryos and Adult Heads by LC-IMS-MS Methods”, J Proteome Research 2005, 4, 1223-1237.
Wong, et al., “Evaluation of Ion Mobility Spectroscopy for Determining Charge-Solvated Versus Salt-Bridge Structures of Protonated Trimers”, Am Soc Mass Spectrom 2005, 16, 1009-1019, Elsevier Inc.
Zeleny, John, “The Distribution of Mobilities of Ions in Moist Air”, Physical Review, vol. 34, Jul. 15, 1929, pp. 310-334.
Zeleny, John, “On the The Ratio of the Velocities of the Two Ions producted in Gases by Rontgen Radiation; and on some Related Phenomena”, philosophical Magazine, No. 46, pp. 120-154.

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