Apparatus and method for operating a differential mobility...

Radiant energy – Ionic separation or analysis

Reexamination Certificate

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C250S282000, C250S288000, C250S42300F, C250S424000

Reexamination Certificate

active

07858927

ABSTRACT:
An apparatus and method of analyzing ions is described in which a Differential Mobility Analyzer (DMA) is combined with an analysis device. The DMS can be operated in first and second modes of operation to produce a plurality of ions that are sampled and analyzed by the analysis device. In the first mode of operation the DMA is configured to enable ion mobility separation and the analysis device samples and analyzes ions having ion mobility in a certain range of ion mobility and in the second mode of operation the DMA is configured to disable ion mobility separation and the analysis device samples and analyzes ions without discrimination based on ion mobility.

REFERENCES:
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patent: 5936242 (1999-08-01), De La Mora et al.
patent: 6700120 (2004-03-01), Hager
patent: 6787763 (2004-09-01), De La Mora et al.
patent: 2009/0101812 (2009-04-01), Thomson
S. Ude et al., “Charge-Induced Unfolding of Multiply Charged Pollyethylene Glycol Ions”, J. Am. Chem. Soc. 2004, 126, pp. 12184-12190.
Juan Fernandez De La Mora et al., “The potential of differential mobility analysis coupled to MS for the study of very large singly and multiply charged proteins and protein complexes in the gas phase”, Biotechnol. J. 2006, 1, pp. 1-10, Wiley-VCH Verlag GmbH & Co.
Juan Fernandez De La Mora et al., “Tandem Mobility Mass Spectrometry Study of Electrosprayed Tetraheptyl Ammonium Bromide Clusters”, J. Am. Soc. Mass Spectrom. 2005, 16, pp. 717-732, Elsevier Inc.

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