Measuring and testing – Surface and cutting edge testing – Roughness
Patent
1998-05-08
1999-11-30
Larkin, Daniel S.
Measuring and testing
Surface and cutting edge testing
Roughness
G01N 2700
Patent
active
059922265
ABSTRACT:
A sample support member for atomic force microscopy of intermolecular interactions includes a sample support base having a plurality of protrusions, each protrusion having an apical substrate region or tip that has been chemically modified by the immobilization thereon of a sample compound or of a linking compound that is capable of binding a sample compound. A reference compound support member has a surface region having at least one reference compound immobilized thereon.
The relative position and orientation of the reference compound support member and the substrate support member are controlled to select a particular protrusion and to cause an interaction between a reference compound immobilized on the surface region of the free end of the cantilever and the sample compound immobilized on the apical substrate area of the selected protrusion. A physical parameter associated with the interaction between the reference compound and the sample compound can be measured.
REFERENCES:
patent: Re33387 (1990-10-01), Binning
patent: Re34489 (1993-12-01), Hansma et al.
patent: 5047663 (1991-09-01), Finlan et al.
patent: 5106729 (1992-04-01), Lindsay et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5144833 (1992-09-01), Amer et al.
patent: 5204581 (1993-04-01), Andreadakis
patent: 5253516 (1993-10-01), Elings et al.
patent: 5260824 (1993-11-01), Okada et al.
patent: 5363697 (1994-11-01), Nakagawa
patent: 5372930 (1994-12-01), Colton et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5463897 (1995-11-01), Prater et al.
patent: 5519212 (1996-05-01), Elings et al.
patent: 5624845 (1997-04-01), Wickramasinghe et al.
patent: 5763768 (1998-06-01), Henderson et al.
patent: 5874668 (1999-02-01), Xu et al.
Erlandsson et al., "Scanning Force Microscopy-Examples of Application to face Chemistry", received Jun. 1992, pp. 1-21.
Nakagawa et al., Discriminating Molecular Length of Chemically Absorbed Molecules Using an Atomic Force Microscope Having a Tip Covered With Sensor Molecules (An Atomic Force Microscope Having Chemical Sensing Function), Jpn. J. Appl. Phys., vol. 32, Par.
Florin E.-L. et al., "Adhesion Forces Between Individual Ligand-Receptor Pairs" Science 264 (1994) pp. 415-417.
Lee et al., "Sensing Discrete Streptavidin-Biotin Interactions with Atomic Force Microscopy" Langmuir, vol. 10 (2), (1994) pp. 354-357.
Dammer et al., "Specific Antigen/Antibody Interactions Measured by Force Microscopy" Biophysical Journal vol. 70 (May 1996) pp. 2437-2441.
Chilikoti et al., "The Relationship Between Ligand-Binding Thermodynamics and Protein-Ligand Interaction Forces Measured by Atomic Force Microscopy" Biophysical Journal vol. 69 (Nov. 1995) pp. 2125-2130.
Allen S. et al., "Detection of Antigen-Antibody Binding Events with the Atomic Force Microscope" Biochemistry, vol. 36, No. 24 (1997) pp. 7457-7463.
Moy V.T. et al., "Adhesive Forces Between Ligand and Receptor Measured by AFM" Colloids and Sufaces A: Physicochemical and Engineering Aspects 93 (1994) pp. 343-348.
Prater, C.B. et al., "Probing Nano-Scale Forces With The AFM" Digital Instruments, Application Notes, at http://www.di.com/AppNotes/ForcCurv/FCMain.html (1995).
"Ultrasharp Silicon Gratings" NT-MDT web site at http://www.ntmdt.ru/grating.htm and http://www.ntmdt.ru/manual/silgrat.htm .
Green John-Bruce DeVault
Lee Gil U
Edelberg Barry A.
Larkin Daniel S.
The United States of America as represented by the Secretary of
Webb Ralph T.
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