Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of culturing cells in suspension
Patent
1989-11-28
2000-04-11
Housel, James C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of culturing cells in suspension
4352865, 4352974, 4352975, 4352991, 4353031, 4353081, 210791, C12M 136
Patent
active
060487275
ABSTRACT:
A mass transfer apparatus and method is based upon use of a mass transfer chamber, such as a hollow fiber membrane bioreactor, with a control to change the directional flow therethrough for enhancement of the mass transfer operation. The invention has particular utility in cell growth systems, where the periodic reversal of flow direction of a nutrient stream passed through the bioreactor equalizes dispersion of cell growth through the bioreactor and enhances the transport of metabolic waste from the cells being grown.
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"Continuous Hybridoma Growth and Monoclonal Antiboy Production in Hollow Fiber Reactors-Separators" Biotechnology an Bioengineering. May 28, 1986.
"CellTronics.TM. HF-100", Product Bulletin New Brunswick Scientific Company, Inc.
Housel James C.
Hultquist Steven J.
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