Liquid purification or separation – With means to add treating material – Chromatography
Patent
1998-08-20
2000-10-17
Therkorn, Ernest G.
Liquid purification or separation
With means to add treating material
Chromatography
210456, 210656, 96101, B01D 1508
Patent
active
061326054
ABSTRACT:
An apparatus and method for sealing cartridges used in liquid chromatography. Such cartridges are commonly filled with media beds that are bounded axially by porous plates. The invention involves one or two sealing heads. Each sealing head comprises two slidably connected head pieces and an elastomeric sealing member. The head pieces and the elastomeric sealing member are sized to slide easily into an open end of a cartridge when the elastomeric sealing member is uncompressed. After insertion, relative movement of the head pieces compresses the elastomeric sealing member and causes the elastomeric sealing member to expand laterally so that it forms a seal against the cartridge, when the sealing head is pressed against the media bed or porous plate. An alternate sealing head comprises a plurality of head pieces and a plurality of annular elastomeric sealing members. One of the head pieces contains a body portion on which the other head pieces and the sealing members are slidably mounted. The sealing apparatus may employ a sample module that fits within an open end of a column or cartridge. At least one of the sealing members fits within the sample module and creates a seal when compressed.
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Pharmacia K 50 Column, p. 3, Pharmacia Laboratory Columns, XK Column System, pp. 424-426.
Leavesley Peter J.
Lockman Robert D.
Van Davelaar Peter C.
Dyax Corporation
Therkorn Ernest G.
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