Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Reexamination Certificate
2003-07-11
2010-11-02
Beisner, William H (Department: 1797)
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
C435S284100, C435S286500
Reexamination Certificate
active
07824848
ABSTRACT:
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
REFERENCES:
patent: 1682344 (1928-08-01), Lesieur
patent: 1916658 (1933-07-01), Davidson
patent: 3406531 (1968-10-01), Swenson et al.
patent: 3545221 (1970-12-01), Swenson et al.
patent: 3607646 (1971-09-01), de Roissart
patent: 3632473 (1972-01-01), Belzer
patent: 3639084 (1972-02-01), Goldhaber
patent: 3654085 (1972-04-01), Norr et al.
patent: 3660241 (1972-05-01), Michielsen
patent: 3712583 (1973-01-01), Martindale et al.
patent: 3738914 (1973-06-01), Thorne et al.
patent: 3753865 (1973-08-01), Belzer et al.
patent: 3772153 (1973-11-01), de Roissart
patent: 3777507 (1973-12-01), Burton et al.
patent: 3810367 (1974-05-01), Peterson
patent: 3843455 (1974-10-01), Bier
patent: 3845974 (1974-11-01), Pelloux-Gervais
patent: 3877843 (1975-04-01), Fischel
patent: 3881990 (1975-05-01), Burton et al.
patent: 3892628 (1975-07-01), Thorne et al.
patent: 3914954 (1975-10-01), Doerig
patent: 3935065 (1976-01-01), Doerig
patent: 3962439 (1976-06-01), Yokoyama et al.
patent: 3995444 (1976-12-01), Clark et al.
patent: 4186565 (1980-02-01), Toledo-Pereyra
patent: 4231354 (1980-11-01), Kurtz et al.
patent: 4242883 (1981-01-01), Toledo-Pereyra
patent: 4243883 (1981-01-01), Schwarzmann
patent: 4378797 (1983-04-01), Osterholm
patent: 4393863 (1983-07-01), Osterholm
patent: 4445500 (1984-05-01), Osterholm
patent: 4451251 (1984-05-01), Osterholm
patent: 4462215 (1984-07-01), Kuraoka et al.
patent: 4471629 (1984-09-01), Toledo-Pereyra
patent: 4473637 (1984-09-01), Guibert
patent: 4474016 (1984-10-01), Winchell
patent: 4494385 (1985-01-01), Kuraoka et al.
patent: 4502295 (1985-03-01), Toledo-Pereyra
patent: 4559298 (1985-12-01), Fahy
patent: 4596250 (1986-06-01), Beisang, III et al.
patent: 4618586 (1986-10-01), Walker
patent: 4629686 (1986-12-01), Gruenberg
patent: 4657532 (1987-04-01), Osterholm
patent: 4666425 (1987-05-01), Fleming
patent: 4704029 (1987-11-01), Van Heuvelen
patent: 4717548 (1988-01-01), Lee
patent: 4723974 (1988-02-01), Ammerman
patent: 4745759 (1988-05-01), Bauer et al.
patent: 4766740 (1988-08-01), Bradley et al.
patent: 4801299 (1989-01-01), Brendel et al.
patent: 4837390 (1989-06-01), Reneau
patent: 4879283 (1989-11-01), Belzer et al.
patent: 4951482 (1990-08-01), Gilbert
patent: 4958506 (1990-09-01), Guilhem et al.
patent: 5003787 (1991-04-01), Zlobinsky
patent: 5013303 (1991-05-01), Tamari et al.
patent: 5028588 (1991-07-01), Hoffman et al.
patent: 5036097 (1991-07-01), Floyd et al.
patent: 5047395 (1991-09-01), Wu
patent: 5051352 (1991-09-01), Martindale et al.
patent: 5066578 (1991-11-01), Wikman-Coffelt
patent: 5085630 (1992-02-01), Osterholm et al.
patent: 5110721 (1992-05-01), Anaise et al.
patent: 5130230 (1992-07-01), Segall et al.
patent: 5141847 (1992-08-01), Sugimachi et al.
patent: 5145771 (1992-09-01), Lemasters et al.
patent: 5149321 (1992-09-01), Klatz et al.
patent: 5157930 (1992-10-01), McGhee et al.
patent: 5200176 (1993-04-01), Wong et al.
patent: 5216032 (1993-06-01), Manning
patent: 5217860 (1993-06-01), Fahy et al.
patent: 5234405 (1993-08-01), Klatz et al.
patent: 5285657 (1994-02-01), Bacchi et al.
patent: 5326706 (1994-07-01), Yland et al.
patent: 5328821 (1994-07-01), Fisher et al.
patent: 5338662 (1994-08-01), Sadri
patent: 5356771 (1994-10-01), O'Dell
patent: 5362622 (1994-11-01), O'Dell et al.
patent: 5383854 (1995-01-01), Safar et al.
patent: 5385821 (1995-01-01), O'Dell et al.
patent: 5395314 (1995-03-01), Klatz et al.
patent: 5434045 (1995-07-01), Jost
patent: 5437633 (1995-08-01), Manning
patent: 5451524 (1995-09-01), Coble et al.
patent: 5472876 (1995-12-01), Fahy
patent: 5584804 (1996-12-01), Klatz et al.
patent: 5586438 (1996-12-01), Fahy
patent: 5599659 (1997-02-01), Brasile et al.
patent: 5622429 (1997-04-01), Heinze
patent: 5643712 (1997-07-01), Brasile
patent: 5681740 (1997-10-01), Messier et al.
patent: 5699793 (1997-12-01), Brasile
patent: 5702881 (1997-12-01), Brasile et al.
patent: 5712084 (1998-01-01), Osgood
patent: 5716378 (1998-02-01), Minten
patent: 5723282 (1998-03-01), Fahy et al.
patent: 5730720 (1998-03-01), Sites et al.
patent: 5821045 (1998-10-01), Fahy et al.
patent: 5823986 (1998-10-01), Peterson
patent: 5843024 (1998-12-01), Brasile
patent: 5856081 (1999-01-01), Fahy
patent: 5879329 (1999-03-01), Ginsburg
patent: 5928182 (1999-07-01), Kraus et al.
patent: 5965433 (1999-10-01), Gardetto et al.
patent: 6024698 (2000-02-01), Brasile
patent: 6046046 (2000-04-01), Hassanein
patent: 6100082 (2000-08-01), Hassanein
patent: 6238908 (2001-05-01), Armstrong et al.
patent: 6300875 (2001-10-01), Schafer
patent: 6673594 (2004-01-01), Owen et al.
patent: 2 226 482 (1973-01-01), None
patent: 221 361 (1985-04-01), None
patent: 38 08 942 (1989-09-01), None
patent: 0 096 997 (1983-12-01), None
patent: 0 256 653 (1988-02-01), None
patent: 0 297 723 (1989-01-01), None
patent: 0 376 763 (1990-07-01), None
patent: 376 763 (1990-07-01), None
patent: 1 208 748 (2002-05-01), None
patent: 545332 (1922-10-01), None
patent: 2 592 306 (1985-12-01), None
patent: 1442356 (1976-07-01), None
patent: 1-213276 (1989-08-01), None
patent: 2-258701 (1990-10-01), None
patent: 760972 (1980-09-01), None
patent: 163 242 8 (1991-07-01), None
patent: WO 86/00812 (1986-02-01), None
patent: WO 88/05261 (1988-07-01), None
patent: WO 91/03934 (1991-04-01), None
patent: WO 91/09520 (1991-07-01), None
patent: WO 91/14364 (1991-10-01), None
patent: 93/00808 (1993-01-01), None
patent: 94/06292 (1994-03-01), None
patent: WO 94/06292 (1994-03-01), None
patent: 96/05727 (1996-02-01), None
patent: WO 96/12191 (1996-04-01), None
patent: WO 96/13288 (1996-05-01), None
patent: 96/32074 (1996-10-01), None
patent: 96/32157 (1996-10-01), None
patent: WO 96/29865 (1996-10-01), None
patent: WO 96/30111 (1996-10-01), None
patent: WO 96/31779 (1996-10-01), None
patent: WO 97/22003 (1997-06-01), None
patent: WO 97/28449 (1997-08-01), None
patent: WO 97/43899 (1997-11-01), None
patent: WO 97/45527 (1997-12-01), None
patent: WO 97/46091 (1997-12-01), None
patent: WO 98/09166 (1998-03-01), None
patent: WO 99/15011 (1999-04-01), None
patent: WO 00/18226 (2000-04-01), None
patent: WO 01/01774 (2001-01-01), None
“Glutathione S-Transferase Predicts Outcome of Machine Preserved NHBN Kidneys”, J.H. Loemen and C. Kootstra, Abstract submitted for presentation at XVIth International Congress of the Transplantation Society, Aug. 1996.
“Renal Preservation After Warm Ischemia Using Oxygen Free Radical Scavengers to Prevent Rep
Brassil John
Brockbank Kelvin G. M.
Burroughs Andrew
Fraser Richard
Harris Stanley
Beisner William H
Lifeline Scientific, Inc.
Oliff & Berridg,e PLC
LandOfFree
Apparatus and method for maintaining and/or restoring... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus and method for maintaining and/or restoring..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for maintaining and/or restoring... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4223561