Apparatus and method for liquid chromatography

Liquid purification or separation – Processes – Chromatography

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210741, 210101, 2101982, 417 43, 417 44, B01D 1508

Patent

active

047754818

ABSTRACT:
To stabilize flow rate in a single-stroke, syringe-type high pressure pump at a constant value after turn-on, a control system increases the pump speed until equilibrium conditions are reached and then pumps at the present rate. In one embodiment, the system is operated in a constant pressure mode under the control of a feedback system to a point at which the pressure is estimated to provide the desired flow rate, with feedback being provided from a pressure measurement and from a flow rate measurement. The feedback from the flow measurement is increased logarithmically with the rate of pumping prior to being compared with the pressure error signal and the comparison between the previous error signal and the logarithmic flow rate signal is used to control the speed of pumping.

REFERENCES:
patent: 4043906 (1977-08-01), Helmer
patent: 4128476 (1978-12-01), Rock
patent: 4237422 (1980-12-01), Lenhardt
"Inexpensive Computers Aid Continuous Fermentation" in CEP, Apr. 1980, Aurthor H. R. Bungay, pp. 53 and 54.

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