Apparatus and method for laser desorption of molecules for quant

Details Apparatus and method for laser desorption of molecules for quant Apparatus and method for laser desorption of molecules for quant

1987-02-24

1991-01-29

Anderson, Bruce CX.

Radiant energy

Ion generation

Field ionization type

250288, 250282, H01J 2724, H01J 4626

Patent

active

049888790

ABSTRACT:
A method and device for volatilizing and thereafter ionizing quantitatable femtomole and smaller amounts of molecules of nonvolatile solid oranic materials is disclosed. The method and device employ a laser pulse to desorb the organic material from a support upon which it is physisorbed. The support and the laser are related to provide a rate of heating of the support surface of at least 10.sup.6 .degree. K./sec with the support withstanding this heating rate without volatilization. Glass and similar inorganic oxidic substrates are preferred. The molecules so generated can be ionized, preferably with the use of resonance-enhanced muiltiphoton ionization. The ions so formed are characterized by a heavy predominance of ions corresponding to the molecules so as to permit their sensitive and unambiguous resolution by mass spectrometry.

REFERENCES:
patent: 4468468 (1984-08-01), Benninghoven et al.
patent: 4658135 (1987-04-01), Alleman et al.
patent: 4745277 (1988-05-01), Banar et al.
patent: 4920264 (1990-04-01), Becker
Hieftje, G. M., Travis, J. C., Lytle, F. E., eds. "Lasers in Chemical Analysis," The Humana Press: Clifton, N.J. 1981.
Kliger, D. S. ed., "Ultrasensitive Laser Spectroscopy", Academic Press, New York, 1983.
Keller, R. A., ed. "Laser-Based Ultrasensitive Spectroscopy and Detection V".
Zare, R. N., Science, 1984, 226 298.
Delgass, W. N., Cooks, R. G., Science 1987, 235 54-5.
Conzemius, R. J., Capellen, J. M., Int. J. Mass Spec. Ion Phys., 1980 34 197.
Burlingame, A. L., Baillie, T. A., Derrick, P. J., Anal. Chem. 1986, 58(5) 165R.
Benninghoven, A. Sichtermann, W. K., Anal. Chem. 1978, 50, 1180.
Anal. Chem., 1978, 50, 985.
Stoll R., Rollgen, F. W., Org. Mass Spec. 1979, 14, 642.
Antonov, V. S., Letokhov, V. S., Shibanov, A. N., Appl. Phys. 1981, 25, 71.
Tabet, J. C., Cotter, R. J., Anal. Chem. 1984, 56, 1662.
Egorov, S. E., Letokhov, V. S. Shibanov, A. N., Chem. Phys. 1984, 85, 349.
Deviney, M. L., Gland, J. L. eds. "Catalyst Characterization Science", American Chemical Society, Washington, D.C., 1985, pp. 238-251.
Karas, M., Bahr, U., Trends in Anal. Chem. 1986, 5, 90.
Wilkins, C. L., Weil, D. A., Yang, C. L. C., Ijames, C. F., Anal. Chem. 1985, 57, 520.
Brown, R. S., Wilkins, C. L., Anal. Chem. 1986, 58, 3196.
Brown, R. S., Wilkins, C. L., J. Am. Chem. Soc. 1986, 108, 2447.
Coates, M. L., Wilkins, C. L., Anal. Chem. 1987, 59 197.
Holm, R., Karas, M., Vogt, H. Anal. Chem. 1987, 59, 373.
Hercules, D. M., Day, R. J., Balasanmugam, K. Dant, T. A. Li, C. P., Anal. Chem. 1982, 54, 280A.
Hercules, D. M., Pure & Appl. Chem. 1983, 55, 1869.
Antonov, V. S., Egorov, S. E., Letokhov, V. S., Shibanov, A. N., JETP LETTER 1983, 38, 217.
Becker, C. H., Gillen, K. T., Anal. Chem. 1984, 56, 1671.
Becker, C. H., Gillen, K. T., J. Opt. Soc. Am. B. 1985, 2, 1438.
Nogar, N. S., Estler, R. C., Miller, C. M., Anal. Chem. 1985, 57, 2441.
Tembreull, R., Lubman, D. M., Anal. Chem. 1986, 58, 1299.
Frey, R., Weiss, G., Kaminski, H., Schlag, E. W., Z. Naturforsch. Teil A 1985, 40 1349.
Walter K., Bosel, U., Schlag, E. W., Int. J. Mass Spectrom. Ion Pro. 1986, 71, 309.

Affiliated with

Also associated with

Rating

Apparatus and method for laser desorption of molecules for quant does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Apparatus and method for laser desorption of molecules for quant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for laser desorption of molecules for quant will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-815796