Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Patent
1999-04-09
2000-11-28
Brusca, John S.
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
436500, 436527, 436536, 436518, 435 71, 424 124, G01N 3348, G01N 3350, G01N 3353, G01N 33546
Patent
active
061547069
ABSTRACT:
An apparatus for predicting a residual hormone concentration in a patient after a removal of a portion of the patient's glandular tissue which secretes the hormone, includes an input device constructed to receive a plurality of measured hormone concentrations corresponding to a plurality of human fluid samples taken from a patient at a plurality of sample times, respectively; and further includes a computer processor configured to iteratively calculate a residual hormone concentration. In accordance with one feature of the present invention, the computer processor is configured to generate data denoting a residual amount of glandular tissue that will remain in the patient after the removal of the portion of the patient's glandular tissue; and the apparatus further comprises an output device constructed to output the generated data denoting the residual amount of glandular tissue. The computer processor is further configured to iteratively calculate a half-life value of the hormone concentration in the patient.
REFERENCES:
Arnold, L, et al, "Automated Immunoassay Systems", Laboratory Instrumentation, Haven, M, et al, eds, Chap 19, 1995, pp 347-352.
Duquenne, M., et al, "Serum parathormone profile during surgical treatment of hyperfunctioning parathyroid adeonoma: a multicompartment model", J Bone and Mineral Res, vol. 9, No. 9, 1994.
Greenblatt, D., Koch-Weser, J. Clinical Pharmocokinetics, Part I, New England Journal of Medicine, vol. 293, No. 14, Oct. 2, 1975 pp 702-5.
Greenbalt, D., Koch-Weser, J, Clinical Pharmocokinetics, Part II, New England Journal of Medicine, vol. 293, No. 19, Nov. 6, 1975, pp 964-970.
Miller Phillip C.
Remaley Alan T.
Ruddel Mark
Brusca John S.
Siu Stephen
Stout Donald E.
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