Apparatus and method for investigating chemical entities

Chemistry: analytical and immunological testing – Optical result

Reexamination Certificate

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Reexamination Certificate

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07579194

ABSTRACT:
An apparatus and method for monitoring a large number of binding interactions and obtaining data related to the interactions. In accordance with the illustrative embodiment, the apparatus includes an IR sensor, a sliding separator, and IR-transmitting fibers that are optically coupled, at a first end thereof, to the sensor. The sliding separator adjusts the spacing between fibers as is required for interfacing the second end of the fibers with any of a variety of sample carriers. The second end of the fibers capture chemical entities form the sample carriers. The chemical entities at the end of the fibers are then contacted with a binding compound. If binding activity occurs, a thermal signal indicative thereof will be transmitted through the fiber to the sensor.

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Goff, D.R. “A Brief History of Fiber Optic Reference Guide.” 3rd Ed., Focal Press. Woburn Massachusetts, 2002.

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