Apparatus and method for in situ detection of areas of cardiac e

Details Apparatus and method for in situ detection of areas of cardiac e Apparatus and method for in situ detection of areas of cardiac e

1995-08-11

1997-10-21

Lateef, Marvin M.

Surgery

Truss

Pad

128656, 128634, 128664, 128665, A61B 500

Patent

active

056785500

ABSTRACT:
An apparatus and method for detecting electrical activity in areas of tissue. The apparatus (1) includes a main catheter (5), multifibered endoscope (10), light filtering means (30, 42, 52), photodetectors (40, 50) and a signal processor (60). The apparatus is used to detect electrical activity by first infusing both an electrically sensitive dye and an electrically insensitive reference dye into the subject tissue and then detecting the intensity of light emitted from both dyes. The wavelength of light emitted from each dye is different. The intensity of light emitted from each dye is similar for non-electrically active tissue and moving tissue but different for electrically active tissue. The intensity of light from the two dyes as separately recorded by the photodetectors is compared by a signal processor to eliminate noise attributable to movement within the area of tissue and arrive at a accurate calculation of electrical activity within the area of tissue.

REFERENCES:
patent: 4768513 (1988-09-01), Suzuki
patent: 4785806 (1988-11-01), Deckelbaum
patent: 5029331 (1991-07-01), Heichler et al.
patent: 5227308 (1993-07-01), Jameson et al.
patent: 5239998 (1993-08-01), Krauthamer
patent: 5273041 (1993-12-01), Richards et al.
patent: 5309907 (1994-05-01), Fang et al.
patent: 5421337 (1995-06-01), Richards-Kortum et al.
patent: 5421339 (1995-06-01), Ramanujam et al.
Krauthamer, Victor In Vitro Toxicology, 6, 109-116 (1993).
Haugland, R.P. "Handbook of Fluorescent Probes and Research Chemicals" 5th Ed., Molecular Probes, Inc., 153-158 (1992).
Montana et al., Biochemistry, 28, 4536-4539 (1989).
Ross et al., Journal of Neuroscience, 4, 659-672 (1984).
De Weer et al., "Optical Methods in Cell Physiology," Society of General Physiologists and Wiley-Interscience, 40, 71-99.
Krauthamer V., Bryant, H.J. et al., Journal of Fluorescence, 1, 207-213 (1991).
Kudo, Y., Takeda, K. et al., J. Neuroscience Methods, 30, 161-168 (1989).
Dillon, S.M. and Wit A.L., Proc. IEEE-BME, 10, 215-216 (1988).

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