Apparatus and method for imaging diseased tissue using integrate

Surgery – Truss – Pad

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128665, 600160, A61B 500, A61B 600, A61B 106

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055906605

ABSTRACT:
An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light image provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

REFERENCES:
patent: 4473841 (1984-09-01), Murakoshi et al.
patent: 4541438 (1985-09-01), Parker et al.
patent: 4556057 (1985-12-01), Hiruma et al.
patent: 4718417 (1988-01-01), Kittrell et al.
patent: 4719508 (1988-01-01), Sasaki et al.
patent: 4768513 (1988-09-01), Suzuki
patent: 4773097 (1988-09-01), Suzaki et al.
patent: 4774568 (1988-09-01), Matsuo
patent: 4786813 (1988-11-01), Svanberg et al.
patent: 4805597 (1989-02-01), Iwakoshi
patent: 4821117 (1989-04-01), Sekiguchi
patent: 4827908 (1989-05-01), Matsuo
patent: 4852579 (1989-08-01), Gilstad et al.
patent: 4858001 (1989-08-01), Milbank et al.
patent: 4860731 (1989-08-01), Matsuura
patent: 4867137 (1989-09-01), Takahashi
patent: 4868647 (1989-09-01), Uehara et al.
patent: 4930516 (1990-06-01), Alfano et al.
patent: 4938205 (1990-07-01), Nudelman
patent: 4957114 (1990-09-01), Zeng et al.
patent: 4993404 (1991-02-01), Lane
patent: 4998972 (1991-03-01), Chin et al.
patent: 5003977 (1991-04-01), Suzuki et al.
patent: 5042494 (1991-08-01), Alfano
patent: 5071417 (1991-12-01), Sinofsky
patent: 5078150 (1992-01-01), Hara et al.
patent: 5090400 (1992-02-01), Saito
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5115137 (1992-05-01), Andersson-Engels et al.
patent: 5131398 (1992-07-01), Alfano et al.
patent: 5196928 (1993-03-01), Karasawa et al.
patent: 5318023 (1994-06-01), Vari et al.
patent: 5377676 (1995-01-01), Vari et al.
patent: 5421337 (1995-06-01), Richards-Kortum et al.
patent: 5421339 (1995-06-01), Ramanujam et al.
Alfano et al. (1987) Fluorescence Spectra from Cancerous and Normal Human Breast and Lung Tissues. IEEE Journal of Quantum Electronics. vol. QE-23, No. 10, pp. 1806-1811.
Andersson-Engels et al. (1989) Tissue Diagnostics Using Laser-Induced Fluorescence. Ber. Bunsenges. Phys. Chem. 93; pp. 335-342.
Coffey et al. (1984) Evaluation of Visual Acuity During Laser Photoradiation Therapy of Cancer. Lasers in Surgery and Medicine 4, pp. 65-71.
Cothren et al. (1990) Gastrointestinal Tissue Diagnosis by Laser-Induced Fluorescence Spectroscopy at Endoscopy Gastrointestinal Endoscopy vol. 36, No. 2, pp. 105-111.
Dougherty et al. (1990) Cutaneous Phototoxic Occurrnces in Patients Receiving Photofrin. Lasers in Surgery and Medicine 10, pp. 485-488.
Hirano et al. (1989) Photodynamic Cancer Diagnosis and Treatment System Consisting of Pulse Lasers and an Endoscopic Spectro-Image Analyzer. Laser in Life Sciences 3(1); pp. 1-18.
Hung et al. (1991) Autofluorescence of Normal and Malignant Bronchial Tissue; Lasers in surgery and Medicine 11, pp. 99-105.
Ikeda (1988) New Bronchial TV Endoscopy System. Elsevier Science Publishers B.V. Biomedial Press.
Kapadia et al. (1990) Laser-Induced Fluorescence Spectroscopy of Human Colonic Mucosa; Gastrenterology 99, pp. 150-157.
Kato et al. (1985) Early Detection of Lung Cancer by Means of Hematoprophyrin Derivative Fluorescence and Laser Photoradiation. Clinics in Chest Medicine vol. 6, No. 2, pp. 237-253.
Kato et al. (1990) Photodynamic Diagnosis in Respiratory Tract Malignancy Using an Excimer Dye Laser System, J. of Photochemistry and Photobiology, B:Biology, 6, pp. 189-196.
Lam et al. Fluorescence Detection. Advances in the Diagnosis and Theraoy of Lung Cancer.
Lam et al. (1990) Detection of Lung Cancer by Ratio Fluorometry with and without Photofrin II; SPIE Proc. 1201, pp. 561-568.
Lam et al. (1990) Detection of Early Lung Cancer Using Low Dose Photofrin II; Chest, vol. 97, pp. 333-337.
Lam et al. (1991) Mechanism of Detection of Early Lung Cancer by Ratio Fluormetry; Lasers in Life Sciences, 4(2); pp. 67-73.
Mullooly et al. (1990) Dihematoporphyrin Ether-Induced Photosensitivity in Photosensitivity in Laryngeal Papilloma Patients. Lasers in Surgery and Medicine 10; pp. 349-356.
Palcic et al. (1990) Development of a Lung Imaging Fluorescence Endoscope. Porceedings of the 12th Annual Intl. Conference of the IEEE Engineering in Medicine and Biology Society. vol. 12, No. 1.
Palcic et al. (1990) The Importance of Image Quality for Computing Texture Features in Biomedical Specimens. SPIE Proc. 1205, pp. 155-162.
Palcic et al. (1991) Lung Imaging Flourescence Endoscope: A Device For Detection of Occult Lung Cancer. Medical Design and Material.
Palcic et al. (1991) Lung Imaging Flourescence Endoscope: Development and Experimental Prototype, SPIE vol. 1448; pp. 113-117.
Palcic et al. (1991) Detection and Localization of Early Lung Cancer by Imaging Techniques CHEST. vol. 99, pp. 742-743.
Peak et al. (1986) DNA-to-Protein Crosslinks and Backbone Breaks Caused by FAR-and NEAR- Ultraviolet and Visible Light Radiations in Mammalian Cells. Mechanism of DNA Damage and Repair, Implications fro Carcinogenisis and Risk Assessment, pp. 193-202.
Profio et al. (1988) Digital Background Subtraction for Fluorescence Imaging; Med. Phys. 13(5); pp. 717-727.
Profio et al. (1991) Endoscopic Fluorescence Detection of Early Lung Cancer; SPIE vol. 1426, pp. 44-46.
Rava et al. (1991) Early Detection of Dysplasia in Colon and Bladder Tissue Using Laser Induced Fluorescence. SPIE vol. 1426; pp. 68-78.
Razum et al.(1987) Skin Photosensitivity: Duration and Intensity Following Intravenous Hematoprophyrin Derivatives, H.sub.P D and DHE, Photochemistry and Photobiology vol. 46, No. 5, pp. 925-928.
Richards-Kortum et al. (1991) Spectroscopic Diagnosis of Colonic Dysplacia; Spectroscopic Analysis Biochemistry and Photobiology, vol. 53, No. 6, pp. 777-786.
Tang et al. (1989) Spectroscopic Differences Between Human Cancer and Normal Lung and Breast Tissues. Lasers in Surgery and Medicine 9; pp. 290-295.
Wagnieres et al. (1990) Photodetection of Early Cancer by Laser Induced Fluorescence of a Tumor-Selective Dye: Apparatus Design and Realization. SPIE Proc. 1203; pp. 43-52.
Wooten et al. (1988) Prospective Studey of Cutaneous Phototoxicity After Systemic Hematoporphyrin Derivative Lasers in Surgery and Medicine 8, pp. 294-300.
Andersson-Engels et al. (1991) Flourescence Characteristics of Atherosclerotic Plaque and Malignant Tumors; SPIE vol. 1426, pp. 31-43.
Profio et al. (1979) Laser Fluorescence Bronchoscope of Occult Lung Tumors; Med. Phys. 6(6), pp. 523-525.
Profio et al. (1984) Fluorometer for Endoscopic Diagnosis of Tumors. Med. Phys. 11(4), pp. 516-520.
Hayata et al. (1982) Fiberoptic Bronchoscopic Laser Photoradiation for Tumor Localization in Lung Cancer; Chest 82, pp. 10-14.
Lam et al. (1990) Fluorescence Imaging of Early Lung Cancer. IEEE Eng. Med. Biol. 12, Ann. Int. Conf.
Montan et al. (1985) Multicolor Imaging and Contrast Enhancement in Cancer-Tumor Localization Using Laser-Induced Fluorescence in Hematoporphyrin--Derivative--bearing Tissue. Optics Letters 10(2) pp. 56-58.

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