Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,...
Reexamination Certificate
2008-04-29
2008-04-29
Warden, Jill (Department: 1797)
Chemistry: analytical and immunological testing
Composition for standardization, calibration, simulation,...
C435S297100, C435S297500, C422S050000, C422S051000, C422S068100
Reexamination Certificate
active
10139766
ABSTRACT:
An article and method for high throughput and a high content investigation of compound interactions with live tissue or its substitutes under controlled conditions during compound absorption and related processes. In some variations of the illustrative embodiment, the article is a multi-chamber enclosure having at least two chambers separated by a membrane. Membranes can be prepared from live epithelial tissue or from an artificial material with or without attached cells from cell-line cultures. Each chamber is advantageously connected to a fluidic-control system by tubes that pass through a feed fitting. In addition to coupling the chambers with the fluidic-control system, the feed fitting, which is spring-biased, provides a sealing force to seal the enclosure. In some variations, one or more multi-chamber enclosures are installed in a mother chamber, which provides controlled environmental conditions. Operation of the article includes automatic introduction of compounds, buffers, and gases into the chambers, establishing reaction conditions inside the chambers, and individually sampling from the chambers.
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Feygin Ilya
Kushak Rafail
Demont & Breyer LLC
Siefke Samuel P
TechElan, LLC
Warden Jill
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