Apparatus and method for high throughput analysis of...

Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S297100, C435S297500, C422S050000, C422S051000, C422S068100

Reexamination Certificate

active

10139766

ABSTRACT:
An article and method for high throughput and a high content investigation of compound interactions with live tissue or its substitutes under controlled conditions during compound absorption and related processes. In some variations of the illustrative embodiment, the article is a multi-chamber enclosure having at least two chambers separated by a membrane. Membranes can be prepared from live epithelial tissue or from an artificial material with or without attached cells from cell-line cultures. Each chamber is advantageously connected to a fluidic-control system by tubes that pass through a feed fitting. In addition to coupling the chambers with the fluidic-control system, the feed fitting, which is spring-biased, provides a sealing force to seal the enclosure. In some variations, one or more multi-chamber enclosures are installed in a mother chamber, which provides controlled environmental conditions. Operation of the article includes automatic introduction of compounds, buffers, and gases into the chambers, establishing reaction conditions inside the chambers, and individually sampling from the chambers.

REFERENCES:
patent: 3590634 (1971-07-01), Pasternak et al.
patent: 3915652 (1975-10-01), Natelson
patent: 3980250 (1976-09-01), Persson
patent: 4744900 (1988-05-01), Bratt
patent: 4889626 (1989-12-01), Browne
patent: 4911713 (1990-03-01), Sauvage et al.
patent: 5183760 (1993-02-01), Sweetana et al.
patent: 5591636 (1997-01-01), Grass
patent: 5738826 (1998-04-01), Lloyd
patent: 6521191 (2003-02-01), Schenk et al.
patent: 2003/0104610 (2003-06-01), Feygin et al.
patent: 2003/0199096 (2003-10-01), Feygin et al.
patent: 2004/0082071 (2004-04-01), Feygin
Harvard Apparatus Catalog, “Cell Biology Section,” pp. M78-M82 (c 2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Apparatus and method for high throughput analysis of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Apparatus and method for high throughput analysis of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for high throughput analysis of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3942654

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.