Apparatus and method for fluorescent excitation and detection fr

Details Apparatus and method for fluorescent excitation and detection fr Apparatus and method for fluorescent excitation and detection fr

1991-07-18

1993-08-31

Cohen, Lee S.

Surgery

Truss

Pad

128634, 128665, A61B 500

Patent

active

052399982

ABSTRACT:
A method of detecting and recording action-potential-related fluorescent changes from a remote tissue situs which has been treated with a voltage-sensitivity dye. The method utilizes a single optical fiber to both direct excitation light to the remote tissue situs and receive emitted fluorescence from the remote tissue situs. The emitted fluorescence from the remote tissue situs is directed to a photomultiplier or photodiode which produces a resulting fluorescence-related signal which is analyzed. The method and related apparatus eliminates signal noise and allows accurate recording and analysis of action-potential-related fluorescent changes.

REFERENCES:
patent: 5101814 (1992-04-01), Palti
Dillon et al, "Use of Voltage Sensitive Dyes to Investigate Electrical Defibrillation", Proc. IEEE-BME, 10, pp. 215-216.
Kudo et al, "A New Device for Monitoring Concentrations of Intracellular Ca.sup.2+ in CNS Preparations and Its Application to the Frog's Spinal Cord", Journal of Neuroscience Methods, vol. 30(1989), pp. 161-168.
Grinvald et al, "Improved Fluorescent Probes for the Measurement of Rapid Changes in Membrane Potential", Biophys. J., vol. 39 (1982), pp. 301-308.
Grinvald et al, "Optical Recording to Synaptic Potentials from Processes of Single Seurons Using Intracellular Potentiometric Dyes", Biophys. J., vol. 51 (1987), pp. 643-651.

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