Coating apparatus – With means to apply electrical and/or radiant energy to work...
Patent
1998-07-01
2000-01-04
Dudash, Diana
Coating apparatus
With means to apply electrical and/or radiant energy to work...
118621, 118622, 118638, 118408, 118409, 118416, 427 211, 427 212, 427 228, 427178, 427346, 427435, 427457, 427481, 4351731, 4351732, 4351734, 4351735, 4351736, 435174, 435176, 4352831, 4352852, B05C 302, B05D 314, C12N 1300, C12N 1500
Patent
active
060105739
ABSTRACT:
An apparatus for modifying an intravascular stent with endothelial cells and/or engineered endothelial cells which may have genetically altered DNA to minimize failure rates includes an external conductor sleeve, an insulating tube held therein, and a pair of insulated end caps, each detachably securable over each end of said insulating tube. Each insulated cap has a substantially centered aperture therethrough and a stent holder extending transversely therefrom to hold opposite ends of the stent therebetween. The insulated end caps and the insulating tube hold a solution containing the endothelial cells inside the insulating tube to surround exposed surfaces of the stent. An insulated internal conductor is received through the apertures. A power source for generating an electrical field between the stent and the external conductor and between the stent and the internal conductor is employed to temporarily alter the electrical charge of the stent to attract and adhere the desired endothelial cells and genetically altered DNA thereto.
REFERENCES:
patent: 4499118 (1985-02-01), Dietz et al.
patent: 4512896 (1985-04-01), Gershoni
patent: 4688239 (1987-08-01), Schaffner et al.
patent: 4939151 (1990-07-01), Bacehowski et al.
patent: 4972569 (1990-11-01), Aoki et al.
patent: 5037378 (1991-08-01), Muller et al.
patent: 5037676 (1991-08-01), Petropoulos et al.
patent: 5078736 (1992-01-01), Behl
patent: 5256141 (1993-10-01), Gencheff et al.
patent: 5304120 (1994-04-01), Crandell et al.
patent: 5534387 (1996-07-01), Lukic
patent: 5714359 (1998-02-01), Bowlin et al.
patent: 5723324 (1998-03-01), Bowlin et al.
patent: 5820917 (1998-10-01), Tuch
patent: 5843741 (1998-12-01), Wong et al.
patent: 5939145 (1999-08-01), Oram
Dotter et al., Transluminal Treatment of Arteriosclerotic Obstruction, Circulation, Vol. XXX (Nov. 1964), pp. 654-670.
Graham et al., Expanded Polytetrafluoroethylene Vascular Prostheses Seeded with Enzymatically Derived and Cultured Canine Endothelial Cells, Surgery, vol. 91, No. 5 (May, 1982), pp. 550-559.
Stanley et al., Enhanced Patency of Small-Diameter, Externally Supported Dacron Iliofemoral Grafts Seeded with Endothelial Cells, Surgery, vol. 92, No. 6 (Dec. 1982), pp. 994-1005.
Popov et al, Mechanism of Cell Protrusion Formation in Electrical Field: the role of actin, Biochimica et Bioplysica Acta 1066 (1991), pp. 151-158.
Tian Y. Tsong, Electroporation of Cell Membranes, Biophys. J. Biophysical Society, Vol. 60 (Aug. 1991), pp. 297-306.
Douville et al., Impact of Endothelial Cell Seeding on Long-Term Patency and Subendothelial Proliferation in a Small-Caliber Highly Porous Polytetrafluoroethylene Graft, Journal of Vascular Surgery, vol. 5, No. 4 (Apr. 1978), pp. 544-550.
Dichek et al., Seeding of Intravascular Stents with Genetically Engineered Endothelial Cells, Circulation, vol. 80, No. 5 (Nov. 1987), pp. 1347-1353.
Flugelman et al., Genetically Engineered Endothelial Cells Remain Adherent and Viable After Stent Deployment and Exposure to Flow in Vitro, Circulation Research, vol. 70, No. 2 (Feb. 1992), pp. 348-354.
Dudash Diana
Virginia Commonwealth University
LandOfFree
Apparatus and method for endothelial cell seeding/transfection o does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus and method for endothelial cell seeding/transfection o, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for endothelial cell seeding/transfection o will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1069554