Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1996-08-09
1999-11-09
Bockelman, Mark
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
607153, 4351736, A61N 130
Patent
active
059831316
ABSTRACT:
The present invention relates to an apparatus and method for localized electroporation of tissue. An apparatus includes a perforate electrically insulating layer, a first electrode at a first side of the perforate electrically insulating layer and a second electrode at a second side of the perforate electrically insulating layer. An electric field extending between the first and second electrodes will preferentially extend through perforations of the electrically insulating layer. The electric field thereby causes electroporation of tissue that is proximate to the first electrode and is partitioned from the electrically insulating layer and the second electrode by the first electrode. The apparatus controllably limits the depth of the electric field within a tissue, such as skin, thereby electroporating a surface layer, such as a stratum corneum layer of the skin, without stimulating submerged nerve endings within the skin. Sensation of the applied voltage and especially pain sensation can thereby be controlled by the invention.
REFERENCES:
patent: 578611 (1897-03-01), Rively
patent: 3078850 (1963-02-01), Schein et al.
patent: 3215139 (1965-11-01), Dietz
patent: 3614955 (1971-10-01), Mirowski et al.
patent: 3680544 (1972-08-01), Shinnick et al.
patent: 4055799 (1977-10-01), Coster et al.
patent: 4081340 (1978-03-01), Zimmermann et al.
patent: 4154668 (1979-05-01), Zimmermann et al.
patent: 4220916 (1980-09-01), Zimmermann et al.
patent: 4411648 (1983-10-01), Davis et al.
patent: 4578168 (1986-03-01), Hofmann
patent: 4663292 (1987-05-01), Wong et al.
patent: 4695547 (1987-09-01), Hilliard et al.
patent: 4764473 (1988-08-01), Matschke et al.
patent: 4784737 (1988-11-01), Ray et al.
patent: 4808152 (1989-02-01), Sibalis
patent: 4822470 (1989-04-01), Chang
patent: 4955378 (1990-09-01), Grasso
patent: 4979948 (1990-12-01), Geddes et al.
patent: 5002527 (1991-03-01), Reller et al.
patent: 5007995 (1991-04-01), Takahashi et al.
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5047007 (1991-09-01), McNichols et al.
patent: 5087240 (1992-02-01), Sibalis
patent: 5098843 (1992-03-01), Calvin
patent: 5137817 (1992-08-01), Busta et al.
patent: 5156591 (1992-10-01), Gross et al.
patent: 5279543 (1994-01-01), Glikfeld et al.
patent: 5296222 (1994-03-01), Petersen et al.
patent: 5298017 (1994-03-01), Theeuwes et al.
patent: 5383848 (1995-01-01), Hillman et al.
patent: 5389069 (1995-02-01), Weaver
patent: 5445609 (1995-08-01), Latin et al.
patent: 5462520 (1995-10-01), Hofmann et al.
patent: 5507724 (1996-04-01), Hofmann et al.
patent: 5547467 (1996-08-01), Pliquett et al.
patent: B15019034 (1995-08-01), Weaver et al.
Mir et al., "Pharmacological Applications of Electropermeaization of Living Cells", Lab. De Biochimie-Enzymologie, Institute Gustave-Roussy 94805 Villejuif Cadex--France.
Zewert et al., "Transdermal Transport of DNA Antisense Oligonucleotides by Electroporation", Biochemical and Biophysical Research Communications 212:286-292 (1995).
Scott et al., "Transport of Ionic Species in Skin: Contribution of Pores to the Overall Skin conductance", Pharmaceutical Research 10:1699-1709 (1993).
Mir et al., "Electrochemotheraph Potentiation of Antitumour Effect of Bleomycin by Local Electric Pulses", Eur. F. Cancer 27(1):68-72 (1991).
Okino et al., "Effects of a High-Voltage Electrical Impulse and an Anticancer Drug on In Vivo Growing Tumors", Jpn. J. Cancer Res. 78(12):1319-1321 (1987).
Heroux et al., "Assessment of Trauma in tissues By Electrica Impedance Measurements", Electromagnetics in Biology and Medicine, pp. 215-221 (1991).
Bhatt et al., "Rhabdomyolysis due to Pulsed Electric Fields" Plastic and Reconstructive Surgery 86(1):1-11 (1990).
Heller et al., "Transfer of Human Membrane Surface Components by Incorporating Human Cells into Intact Animal Tissue by Cell Tissue Electrofusion In Vivo", Biochimica et Biophysica Acta 1024:185-188 (1990).
Titomirov et al., "In Vivo Electroporation and Stable Transformation of Skin Cells of Newborn Mice by Plasmid DNA", Biochimica et Biophysica Acta. 1088:131-134 (1991).
Okino, et al., Journal of Japan Soc. For Cancer Therapy 22(8):337 (1987).
Kanesda, et al., Journal of Japan Soc. For Cancer Therapy 22(8):338 (1987).
Okino et al., Japan Journal of Cancer Research 46:420 (1987).
Weaver, "Electroporation: A General Phenomenon for Manipulating Cells and Tissues", Journal of Cellular Biochemistry 51:426-435 (1993).
Prausnitz et al., "Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery", Proc. Natl. Acad. Sci. USA 90:10504-10508 (1993).
Prausnitz et al., "Methods for in Vivo Tissue Electroporation Using Surface Electrodes", Academic Press, Inc. Drug Delivery 1:125-131 (1993).
Bergan et al., "Electroporation enhances c-myc antisense oligodeoxynucleotide efficacy", Nucleic Acids Research 21(15):3567-3573.
Zewert et al., "Transdermal Transport of DNA Antisense Oligonucleotides by Electroporation", Biochemical and Biophysical Research Comm. 212(2):286-292.
Zimmermann et al., "Effects of External Electrical Fields on Cell Membranes", Bioelectrochemistry and Bioenergetics 3:58-83 (1976).
Tamada et al., "Measurement of Glucose in Diabetic Subjects Using Noninvasive Transdermal Extraction", Nature Medicine 1:1198-1202 (1995).
Dinh et al., "Upper and Lower Limits of Human Skin Electrical Resistance in Iontophoresis", American Institute of Chemical Engineers Joural 39(12):2011-2018 (1993).
Pliquett et al., "Imaging of Fluorescent Molecules and Small Ion Transport Through Human Stratum Corneum During High-Voltage Pulsing: Localized Transport Regions are Involved", J. Biophysical Chemistry 58:185-204 (1996).
Pliquett et al., "Changes in the Passive Electrical Properties of Human Stratum Corneum Due to Electroporation", Biochemica et Biophysica Acta 1239:111-121 (1995).
Edwards et al., "Analysis of Enhanced Transdermal Transport by Skin Electroporation", Journal of Controlled Release 34:211-221 (1995).
Pliquett Uwe
Vaughan Timothy
Weaver James C.
Bockelman Mark
Massachusetts Institute of Technology
LandOfFree
Apparatus and method for electroporation of tissue does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus and method for electroporation of tissue, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for electroporation of tissue will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1469134