Apparatus and method for electrically contacting biological...

Details Apparatus and method for electrically contacting biological... Apparatus and method for electrically contacting biological...

2008-04-22

2008-04-22

Beisner, William H. (Department: 1797)

Chemistry: molecular biology and microbiology

Apparatus

Mutation or genetic engineering apparatus

C435S287100, C435S288500

Reexamination Certificate

active

07361500

ABSTRACT:
An apparatus for electrically contacting biological cells suspended in a liquid has a substrate having at least one opening and an electrode for electrically contacting a cell immobilized above the opening. A contact unit with a contact tip is arranged below said opening. A top end of the contact tip projects into the opening in such a way that it comes to bear against a cell membrane of the immobilized cell. The contact tip has a contact channel which ends at its top end. A hydrodynamic low pressure can be exerted upon the cell membrane via the contact channel, and the electrode is electrically connected to the contact channel. In a method for electrically contacting biological cells suspended in a liquid, a cell is immobilized above an opening provided in a substrate, and the immobilized cell is contacted via at least one electrode. For contacting the immobilized cell, a hydrodynamic low pressure is generated acting on a cell membrane through a contact tip projecting into the opening.

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Neher et al., “The Patch Clamp Techniques,”Scientific American, Mar. 1992, pp. 28-35.

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