Measuring and testing – Sampler – sample handling – etc. – Automatic control
Patent
1998-05-29
1999-11-09
Noori, Max
Measuring and testing
Sampler, sample handling, etc.
Automatic control
324 714, G01N 100
Patent
active
059792515
ABSTRACT:
Substrate beads for combinatorial synthesis are selected individually from a mixture by suspending the mixture in an electrically conductive liquid, in a bead selection vessel, causing the liquid to flow at a controlled rate through an aperture in the side wall of a pipette extending through the vessel, and detecting the passage of a bead through the aperture by monitoring an electrical resistance across the aperture. In an alternative embodiment, beads are passed through a tube into a collection passage in which a continuous laminar flow takes place. Detection takes place at the tip of the tube, and, in response to the detection of a bead, the flow through the collection passage is diverted to cause the bead to be deposited. In both cases, the selected bead is deposited into a well of a plate having rows and columns of wells in a rectangular array, while a vacuum is drawn through a filter in the bottom of the well. The bead selection head is moved from well to well in each column, and the well plate is indexed to position the columns successively underneath the path of the bead selection vessel. A plate handling mechanism retrieves plates from a supply stack, moves them laterally underneath the bead selection vessel, and elevates them into another stack.
REFERENCES:
patent: 2656508 (1953-10-01), Coulter
patent: 4170699 (1979-10-01), Wright
patent: 4818492 (1989-04-01), Shimizu
patent: 5076097 (1991-12-01), Zarrin et al.
patent: 5245530 (1993-09-01), Taki
patent: 5415051 (1995-05-01), Rokugawa et al.
Hare John F.
James Philip J.
Marlow John
Payne Richard C.
King William T.
Kinzig Charles M.
Noori Max
SmithKline Beecham p.l.c.
Venetianer Stephen
LandOfFree
Apparatus and method for distributing beads does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus and method for distributing beads, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for distributing beads will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1442265