Optics: measuring and testing – Blood analysis
Patent
1997-03-24
1999-04-27
Kim, Robert H.
Optics: measuring and testing
Blood analysis
600320, 600322, 422 8205, 436 66, G01N 3348, A61B 500
Patent
active
058984879
ABSTRACT:
An apparatus for determining the concentrations of n hemoglobin derivatives in a sample of undiluted, unhemolyzed whole blood provided in a cuvette, employs a device producing a primary light beam formed of at least n substantially monochromatic, narrow-band components of different wavelengths. Further provided is a detection device for measuring of the radiation passing through the cuvette. At least two measuring geometries are provided for spectral detection of a collimated central beam and at least one scatter beam, and detection of the central beam departing from a first measuring location in the cuvette takes place in a first measuring position on the axis of the primary beam, and detection of the scatter beam takes place in a second measuring position if it departs from the first measuring location in the cuvette, or in the first measuring position if it departs from a second measuring location in the cuvette, whereby the axes of the central beam and the scatter beam(s) enclose angles .alpha..sub.i, and the evaluation device includes a unit for calculating the concentrations of the n hemoglobin derivatives from the at least 2n measurement values obtained in the at least two measuring geometries and a predetermined calibration matrix.
REFERENCES:
patent: 5331958 (1994-07-01), Oppenheimer
patent: 5372135 (1994-12-01), Mendelson et al.
patent: 5616501 (1997-04-01), Rodriguez et al.
International Publication No. WO 94/08237 to A.P. Shepherd et al., dated Apr. 14, 1994, entitled, "Method and Apparatus for Direct Spectrophotometric Measurements in Unaltered Whole Blood".
AVL Medical Instruments AG
Kim Robert H.
Smith Zandra V.
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