Apparatus and method for determining the concentration of...

Chemistry: analytical and immunological testing – Halogen containing – In aqueous solution

Reexamination Certificate

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C436S124000, C436S126000, C436S164000, C436S169000, C436S177000

Reexamination Certificate

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07858379

ABSTRACT:
A method for determining the amount of a known iodine-containing organic compound in an aqueous solution. The method comprises electrochemically reducing the known iodine-containing organic compound in an aqueous medium to release iodide anions, chemically oxidizing the iodide anions to produce molecular iodine, and measuring the amount of molecular iodine. The known iodine-containing organic compound is preferably an aryl iodide, such as Iothalamate. Other preferred iodine-containing organic compounds include various glomerular filtration rate (GFR) marker compounds in plasma or urine samples, as useful in the measurement of GFR for an animal. The electrochemical reduction of the known iodine-containing organic compound is preferably performed in an electrochemical cell including a working electrode separated from a counter electrode by a cation exchange membrane. The working electrode most preferably includes bismuth and the counter electrode most preferably includes platinum.

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Arena, Matteo P. et al. “Rapid, Specific Determination of Iodine and Iodide by Combined Solid-Phase Extraction/Diffuse Reflectance Spectroscopy”, Microanalytical Instrumentation Center, Iowa State University, Analytical Chemistry, vol. 74, No. 1, Jan. 1, 2002, pp. 185-190.
Argawal, Omi et al. A Sensitive Colorimetric Method for the Micro Determination of Iodine in Marine Water:, Elsevier Talanta, School of Studies in Chemistry, Pt. Ravishankar Shukla University, India, Talanta 49 (1999), pp. 923-928.

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