Apparatus and method for determining serum concentrates of metab

Details Apparatus and method for determining serum concentrates of metab Apparatus and method for determining serum concentrates of metab

1979-06-11

1981-01-13

Prescott, Arthur C.

Chemistry: electrical and wave energy

Processes and products

204195B, 204195P, G01N 2730, G01N 2746, G01N 314

Patent

active

042447879

ABSTRACT:
An apparatus and method are disclosed for monitoring, analyzing and quantitating in real time the concentrations of metabolites in serum by analyzing the dialysate solutions which are being equilibrated with the blood via a hemodialyzer. Thus, access to certain metabolically important species is provided without the necessity of blood sampling. The apparatus includes at least one ion-selective electrode coupled with the dialysate effluent stream, and the electrode EMF is converted to dialysate concentrations based on precalibration. The dialysate concentrations, in turn, are related to serum levels by factors governing mass transfer through the dialyzer.

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patent: 3902970 (1975-09-01), Levin
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